机构：[1]Central Laboratory, Department of Endocrinology, Second People’s Hospital of Yunnan Province, Kunming, China.[2]Nuclear Medicine Department, Second Affiliated Hospital of Kunming Medical University, Kunming, China.[3]First Affiliated Hospital of Medical College, Shihezi University, Shihezi, China.[4]Cardiology Laboratory of Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
The uncoupling protein 2 (UCP2) gene plays an important role in the complications of type 2 diabetes (T2D). However, the association between variants in the UCP2 gene and diabetic retinopathy (DR) in Han Chinese T2D patients remains unclear.
Two single-nucleotide polymorphisms (SNPs) [rs659366 (-866G/A) and a 45-bp insertion/deletion (I/D) in the 3'-UTR] in the UCP2 gene were genotyped in a study cohort of 209 T2D patients with DR and 199 T2D patients without DR by direct DNA sequencing.
Logistic regression analysis showed that the AA and GA genotypes of rs659366 were significantly associated with an increased risk for nonproliferative DR (NPDR) in the codominant model (corrected p-value <0.01) and the dominant model (corrected p-value = 0.006). Patients harboring the II and DI genotypes had a higher risk for PDR in the codominant model (corrected p-value = 0.011) and the dominant model (corrected p-value = 0.006), and the DI genotype showed a higher risk for NPDR in the dominant model (corrected p-value = 0.007) or codominant model (corrected p-value = 0.006). Further, haplotype analyses verified that the A-I haplotype is a risk haplotype for NPDR and PDR.
This study suggests that the UCP2 gene may be involved in the pathogenesis of NPDR and PDR in Han Chinese patients with T2D.
基金：
This work was supported by grants
from the Natural Science Foundation of China (No. 81760734)
and the Natural Science Foundation of Yunnan Province (No.
2017FA048), Specific Association Foundation Program of Yunnan Provincial Science and Technology Department and
Kunming Medical University (No. 2017FE468 and No.
2014FA016), the Fund ofDiabetic Innovation TeamofYunnan
Province, and Found of Yunnan Province’s Key Clinical Specialties
and Fund of Medical Leader in Yunnan Province (No.
L-201609).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|4 区生物
小类|4 区遗传学
最新[2023]版：
大类|4 区生物学
小类|4 区遗传学
第一作者：
第一作者机构：[1]Central Laboratory, Department of Endocrinology, Second People’s Hospital of Yunnan Province, Kunming, China.
共同第一作者：
推荐引用方式(GB/T 7714)：
Zhou Tai-Cheng,Yang Lei,Liu Yong-Ying,et al.Polymorphisms in the Uncoupling Protein 2 Gene Are Associated with Diabetic Retinopathy in Han Chinese Patients with Type 2 Diabetes.[J].Genetic testing and molecular biomarkers.2018,22(11):637-643.doi:10.1089/gtmb.2018.0115.
APA：
Zhou Tai-Cheng,Yang Lei,Liu Yong-Ying,Qin Yuan,Li Yi-Ping...&Yang Ying.(2018).Polymorphisms in the Uncoupling Protein 2 Gene Are Associated with Diabetic Retinopathy in Han Chinese Patients with Type 2 Diabetes..Genetic testing and molecular biomarkers,22,(11)
MLA：
Zhou Tai-Cheng,et al."Polymorphisms in the Uncoupling Protein 2 Gene Are Associated with Diabetic Retinopathy in Han Chinese Patients with Type 2 Diabetes.".Genetic testing and molecular biomarkers 22..11(2018):637-643
