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Cytotoxic monoterpenoid indole alkaloids from the aerial parts of Kopsia officinalis.

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机构： [1]Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China. [2]Department of General Practice, The Second Affiliated Hospital of Dalian Medical University, Dalian 116023, China. [3]College of Biological Resources and Food Engineering, Qujing Normal University, Qujing 655011, China. [4]Tumor Hospital of Yunnan Province, The Third Affiliated Hospital of Kunming Medical University, Kunming 650118, China.

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摘要：

Three new monoterpenoid indole alkaloids, kopsiaofficines A-D (1-3), were isolated from the 95% EtOH extract of the aerial parts of Kopsia officinalis. Their structures were established on the basis of spectroscopic data. The isolated alkaloids were tested in vitro for cytotoxic activity against seven lung cancer cell lines. Consequently, alkaloids 1 and 3 exhibited some cytotoxic activities against all the tested tumor cell lines with IC50 values less than 20 µM.[Formula: see text].

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出版当年[2020]版：

大类 | 4 区医学

小类 | 4 区应用化学 4 区药物化学 4 区药学 4 区植物科学

最新[2023]版：

大类 | 3 区医学

小类 | 4 区应用化学 4 区药物化学 4 区药学 4 区植物科学

第一作者：

第一作者机构： [1]Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China. [2]Department of General Practice, The Second Affiliated Hospital of Dalian Medical University, Dalian 116023, China.

通讯作者：

通讯机构： [1]Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China. [*1]Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China

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