机构：[1]Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230001, China[2]State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei, Anhui 230036, China[3]Neurodegenerative Disease Research Center, University of Science and Technology of China, Hefei, Anhui 230026, China[4]Organ Transplantation Center, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui 23000^, China[5]CAS Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, Yunnan 65Q223, China[6]National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, Anhui 230029, China[7]CAS Key Laboratory of Brain Function and Disease, University of Science and Technology of China, Hefei, Anhui 230026, China
Exosomes are small vesicles secreted by all cell types in the brain and play a role in cell-cell communication through the transfer of cargo or encapsulation. Exosomes in the brain have considerable impact on neuronal development, activation, and regeneration. In addition, exosomes are reported to be involved in the onset and propagation of various neurodegenerative diseases. In this review, we discuss the content of exosomes derived from major cell types in the brain, and their function under physiological and pathological conditions.
基金：
National
Natural Science Foundation of China (31871082, 91849101,
81601221), The Strategic Priority Research Program of the Chinese
Academy of Sciences (XDB39000000), Key Research Program of
Frontier Sciences of CAS (QYZDB-SSW-SMC035), the Innovative
Program of Development Foundation of Hefei Center for Physical
Science and Technology (2018CXFX005), the Fundamental Research
Funds for the Central Universities, and China Postdoctoral Science
Foundation (2019M662178). The Open Fund of State Key Laboratory
of Tea Plant Biology and Utilization (SKLTOF20150101)
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类|1 区生物
小类|1 区动物学
最新[2023]版：
大类|1 区生物学
小类|1 区动物学
第一作者：
第一作者机构：[1]Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230001, China[3]Neurodegenerative Disease Research Center, University of Science and Technology of China, Hefei, Anhui 230026, China[7]CAS Key Laboratory of Brain Function and Disease, University of Science and Technology of China, Hefei, Anhui 230026, China
共同第一作者：
通讯作者：
通讯机构：[1]Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230001, China[3]Neurodegenerative Disease Research Center, University of Science and Technology of China, Hefei, Anhui 230026, China[5]CAS Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, Yunnan 65Q223, China[7]CAS Key Laboratory of Brain Function and Disease, University of Science and Technology of China, Hefei, Anhui 230026, China
推荐引用方式(GB/T 7714)：
Li Xiao-Hui,Zhang Juan,Li Ding-Feng,et al.Physiological and pathological insights into exosomes in the brain.[J].Zoological Research.2020,41(4):365-372.doi:10.24272/j.issn.2095-8137.2020.043.
APA：
Li Xiao-Hui,Zhang Juan,Li Ding-Feng,Wu Wei,Xie Zhong-Wen&Liu Qiang.(2020).Physiological and pathological insights into exosomes in the brain..Zoological Research,41,(4)
MLA：
Li Xiao-Hui,et al."Physiological and pathological insights into exosomes in the brain.".Zoological Research 41..4(2020):365-372
生物