机构：[1]Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan China.[2]Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, Xinxiang, Henan China.[3]The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan China.[4]Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan China.[5]Henan Province People's Hospital, Zhengzhou, Henan China.
Genome-wide association studies (GWAS) suggest that rs9371601 in the SYNE1 gene is a risk SNP for bipolar disorder (BPD) in populations of European ancestry, but further replication analyses across distinct populations are needed.
We analyzed the association between rs9371601 and BPD in a Han Chinese sample of 1315 BPD cases and 1956 controls.
We observed a significant association between rs9371601 and BPD in Han Chinese (p = 0.0121, OR = 0.859). However, further examinations revealed that the Europeans and Chinese subjects had different BPD risk alleles at the locus. We then found that rs9371601 had different "minor alleles" and distinct linkage disequilibrium (LD) patterns surrounding itself in Europeans and Han Chinese, which might be the explanation of the observed inconsistent association signals for this locus in different populations. Our explorative analyses of the biological impact of rs9371601 suggested that this SNP was significantly associated with the methylation of a CpG site (cg01844274, p = 5.05⨯10- 6) within SYNE1 in human dorsal lateral prefrontal cortex (DLPFC) tissues.
Our data confirms the association between rs9371601 and BPD, but the underlying biological mechanism remains to be fully elucidated in further studies.
基金：
This study was supported by the National Natural Science Foundation of
China (grant numbers, 81671330 to LX-L), the High Scientific and Technological Research Fund of Xinxiang Medical University (grant numbers,
2017ZDCG-04 to LX-L), the Medical science and technology research project
of Henan Province (201702131 to YF-Y), the Fundamental and Advancing
Foundation of Henan Province (132300413216 to LX-L), the Training plan for
young excellent teachers in Colleges and Universities of Henan
(NO.2016GGJS-106 to WQ-L), the Science and technology project of Xinxiang
(CXGG17030 to WQ-L), and the support project for the Disciplinary group of
Psychiatry and Neuroscience, Xinxiang Medical University.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|4 区生物
小类|4 区遗传学
最新[2023]版：
大类|3 区生物学
小类|4 区遗传学
第一作者：
第一作者机构：[1]Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan China.[2]Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, Xinxiang, Henan China.
通讯作者：
通讯机构：[1]Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan China.[2]Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, Xinxiang, Henan China.[5]Henan Province People's Hospital, Zhengzhou, Henan China.
推荐引用方式(GB/T 7714)：
Li Wenqiang,Yang Yongfeng,Luo Binbin,et al.Association of SYNE1 locus with bipolar disorder in Chinese population.[J].Hereditas.2019,156:19.doi:10.1186/s41065-019-0095-7.
APA：
Li Wenqiang,Yang Yongfeng,Luo Binbin,Zhang Yan,Song Xueqin...&Lv Luxian.(2019).Association of SYNE1 locus with bipolar disorder in Chinese population..Hereditas,156,
MLA：
Li Wenqiang,et al."Association of SYNE1 locus with bipolar disorder in Chinese population.".Hereditas 156.(2019):19
