机构：[1]Hefei National Laboratory for Physical Sciences at the Microscale, Neurodegenerative Disorder Research Center, CAS Key Laboratory of Brain Function and Disease, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.[2]College of Biology, Food and Environment, Hefei University, Hefei, China.[3]Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.[4]KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.[5]Department of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.[6]Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.[7]Eye Center, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.[8]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.
Besides generating vision, light modulates various physiological functions, including mood. While light therapy applied in the daytime is known to have anti-depressive properties, excessive light exposure at night has been reportedly associated with depressive symptoms. The neural mechanisms underlying this day-night difference in the effects of light are unknown. Using a light-at-night (LAN) paradigm in mice, we showed that LAN induced depressive-like behaviors without disturbing the circadian rhythm. This effect was mediated by a neural pathway from retinal melanopsin-expressing ganglion cells to the dorsal perihabenular nucleus (dpHb) to the nucleus accumbens (NAc). Importantly, the dpHb was gated by the circadian rhythm, being more excitable at night than during the day. This indicates that the ipRGC→dpHb→NAc pathway preferentially conducts light signals at night, thereby mediating LAN-induced depressive-like behaviors. These findings may be relevant when considering the mental health effects of the prevalent nighttime illumination in the industrial world.
基金：
The authors thank L.Q. Luo, X.K. Chen, Z.L. Qiu and X.H. Xu for their critical reading
of the manuscript and their insightful advice. We also thank Y. Cai and X.Y. Zhou for
their intellectual input and technical support. We thank members of the Neuroscience
Pioneer Club for insightful discussions throughout the course of this study. This work
was funded by the Strategic Priority Research Program of the Chinese Academy of
Science (grant no. XDA16020603 to T.X.), the National Natural Science Foundation of
China (grant nos. 81790644, 81925009 and 91432104 to T.X., 61890953 to J.B., 31601134
and 61727811 to H.Z., 91432104 to J.-T.C. and 81900855 to M.Z.), the Anhui Provincial
Natural Science Foundation (grant no. 1708085QC57 to H.Z., 1808085MH289 to M.Z.
and 1908085MC66 to J.-J.M.), the National Key Basic Research Program of China (grant
no. 2016YFA0400900 to T.X.), the CAS priority research program (grant nos. XDPB10
and XDB02010000 to T.X.), the Innovative Program (grant no. ZT00102901 to H.Z.), the
User with Excellence Program of Hefei Science Center CAS (grant no. 2019HSC-UE018
to T.X.), the Fundamental Research Funds for the Central Universities(grant no.
WK2070000174 to T.X., M.Z. and Y.-Q. M.) and The Key Program in the Youth Elite
Support Plan in Universities of Anhui Province (grant no. gxyqZD2018020 to Q.X.).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类|1 区医学
小类|1 区神经科学
最新[2023]版：
大类|1 区医学
小类|1 区神经科学
第一作者：
第一作者机构：[1]Hefei National Laboratory for Physical Sciences at the Microscale, Neurodegenerative Disorder Research Center, CAS Key Laboratory of Brain Function and Disease, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
共同第一作者：
通讯作者：
通讯机构：[1]Hefei National Laboratory for Physical Sciences at the Microscale, Neurodegenerative Disorder Research Center, CAS Key Laboratory of Brain Function and Disease, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.[6]Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.[7]Eye Center, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.[8]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.
推荐引用方式(GB/T 7714)：
An Kai,Zhao Huan,Miao Ying,et al.A circadian rhythm-gated subcortical pathway for nighttime-light-induced depressive-like behaviors in mice.[J].Nature neuroscience.2020,23(7):869-880.doi:10.1038/s41593-020-0640-8.
APA：
An Kai,Zhao Huan,Miao Ying,Xu Qi,Li Yu-Fei...&Xue Tian.(2020).A circadian rhythm-gated subcortical pathway for nighttime-light-induced depressive-like behaviors in mice..Nature neuroscience,23,(7)
MLA：
An Kai,et al."A circadian rhythm-gated subcortical pathway for nighttime-light-induced depressive-like behaviors in mice.".Nature neuroscience 23..7(2020):869-880
医学