机构：[1]Key Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Hospital of China MedicalUniversity, Shenyang, China,[2]Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China,[3]AIDS Research Center, NationalInstitute of Infectious Diseases, Tokyo, Japan,[4]Infectious Disease Department, Guangzhou No. 8 Renmin Hospital, Guangzhou, China,[5]AIDS/STIs Prevention and ControlDepartment, Hunan Provincial Center for Disease Control and Prevention, Changsha, China,[6]Sexually transmitted Disease and AIDS Department, Shandong ProvincialCenter for Disease Control and Prevention, Jinan, China,[7]Henan Provincial Center for Disease Control and Prevention, Zhengzhou, China,[8]Sexually transmitted Diseaseand AIDS Department, Anhui Provincial Center for Disease Control and Prevention, Hefei, China,[9]Yunnan Provincial Center for Disease Control and Prevention, Kunming,China,[10]Sexually transmitted Disease and AIDS Department, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China,[11]Infectious DiseasesDepartment, Beijing Youan Hospital, Capital Medical University, Beijing, China,[12]Sexually Transmitted Disease and AIDS Prevention and Control Department, JiangsuProvincial Center for Disease Control and Prevention, Nanjing, China
The HIV-1 epidemic among men-who-have-sex-with-men (MSM) continues to expand in China. A large-scale national survey we conducted on HIV-1 strains among MSM in 11 provinces in China from 2008 to 2013 (n = 920) identified a novel transmission cluster consisting of six strains (0.7%) that belonged to a new circulating recombinant form (designated CRF59_01B). CRF59_01B contains two subtype B segments of U.S.-European origin (in the pol and vpu-env regions) in a CRF01_AE backbone. CRF59_01B is the second CRF (after CRF55_01B) circulating primarily among MSM in China. CRF59_01B occurs at a low frequency (less than 1%), but it was detected in four different provinces/regions in China: Liaoning (northeast China) (n = 3); Hunan (central China) (n = 1); Guangdong (south China) (n = 1); Yunnan (southwest China) (n = 1). One additional recombinant strain was detected in a heterosexual individual in Liaoning province but is not the focus of this paper. Bayesian molecular clock analyses indicate that CRF59_01B emerged as a result of recombination between CRF01_AE and subtype B around the year 2001. The emergence of multiple forms of recombinants and CRFs reflects the ever-increasing contribution of homosexual transmission in China's HIV epidemic and indicates an active HIV transmission network among MSM in China.
基金：
Mega-projects of National Science Research for the 12th Five-Year Plan (2012ZX10001-006), Liaoning Province Department
of Higher Education Programme for Excellence in Research 2012 (LJQ2012068), Bill and Melinda Gates Foundation, Development Programme of the innovative
group by Ministry of Education, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China.
第一作者机构：[1]Key Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Hospital of China MedicalUniversity, Shenyang, China,[2]Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China,
共同第一作者：
通讯作者：
通讯机构：[1]Key Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Hospital of China MedicalUniversity, Shenyang, China,[2]Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China,[3]AIDS Research Center, NationalInstitute of Infectious Diseases, Tokyo, Japan,
推荐引用方式(GB/T 7714)：
Weiqing Zhang.,Xiaoxu Han.,Minghui An,et al.Identification and characterization of a novel HIV-1 circulating recombinant form (CRF59_01B) identified among men-who-have-sex-with-men in China[J].PLOS ONE.2014,9(6):doi:10.1371/journal.pone.0099693.
APA：
Weiqing Zhang.,Xiaoxu Han.,Minghui An,Bin Zhao,Qinghai Hu...&Hong Shang.(2014).Identification and characterization of a novel HIV-1 circulating recombinant form (CRF59_01B) identified among men-who-have-sex-with-men in China.PLOS ONE,9,(6)
MLA：
Weiqing Zhang.,et al."Identification and characterization of a novel HIV-1 circulating recombinant form (CRF59_01B) identified among men-who-have-sex-with-men in China".PLOS ONE 9..6(2014)
