机构：[a]The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China[b]Institute of Organ Transplantation of Xi’an Jiaotong University,Xi’an, China[c]The First Affiliated Hospital Of Sun Yat-sen University, Guangzhou, China中山大学附属第一医院[d]First Affiliated Hospital Of Zhejiang UniversityMedical School, Hangzhou, China浙江大学医学院附属第一医院[e]The Chinese People’s Liberation Army 923 Hospital, Nanjing, China[f]Second People’s Hospital ofShanxi Province, Taiyuan, China[g]The Second Xiangya Hospital Of Central South University, Changsha, China[h]Tongji HospitalAffiliated to Tongji Medical College Huazhong University of Science and Technology, Wuhan, China华中科技大学同济医学院附属同济医院[i]People’s Hospital of ZhengzhouCity, Zhengzhou, China[j]Beijing Chaoyang Hospital Affiliated to The Capital University of Medical Sciences, Beijing, China北京朝阳医院[k]BethuneFirst Hospital of Jilin University, Changchun, China[l]The Affiliated Hospital of Qingdao University, Qingdao, China[m]The SecondAffiliated Hospital of Guangzhou Medical University, Guangzhou, China[n]The First Affiliated Hospital Of Zhengzhou University,Zhengzhou, China[o]West China Hospital of Sichuan University, Chengdu, China四川大学华西医院[p]The First Affiliated Hospital of the First ShandongMedical University, Jinan, China[q]Nanfang Hospital of Southern Medical University, Guangzhou, China[r]The Third Hospital Affiliatedof Sun-Yet University, Guangzhou, China[s]Kunming City First People’s Hospital, Kunming, China[t]People’s Hospital of WuhanUniversity, Wuhan, China[u]Changhai Hospital of Naval Military Medical University, Shanghai, China[v]Zhujiang Hospital, of SouthernMedical University, Guangzhou, China南方医科大学珠江医院[w]The 900 Hospital of Joint Logistic Support Department of PLA, Fuzhou, China[x]ZhongnanHospital of Wuhan University, Wuhan, China[y]The Eighth Medical Center of People’s Liberation Army General Hospital, Beijing, China[z]The Third Xiangya Hospital of Central South University, Changsha, China[aa]Zhongshan Hospital Affiliated to Fudan University,Shanghai, China[ab]The 924 Hospital of Joint Logistic Support Department of PLA, Guilin, China[ac]The Second Affiliated Hospital ofArmy Military Medical University, Chongqing, China[ad]Tianjin First Central Hospital, Tianjin, China
Background Kidneys obtained from deceased donors increase the incidence of delayed graft function (DGF) after renal transplantation. Here we investigated the influence of the risk factors of donors with DGF, and developed a donor risk scoring system for DGF prediction. Methods This retrospective study was conducted in 1807 deceased kidney donors and 3599 recipients who received donor kidneys via transplants in 29 centers in China. We quantified DGF associations with donor clinical characteristics. A donor risk scoring system was developed and validated using an independent sample set. Results The incidence of DGF from donors was 19.0%. Six of the donor characteristics analyzed, i.e., age, cause of death, history of hypertension, terminal serum creatinine, persistence of hypotension, and cardiopulmonary resuscitation (CPR) time were risk factors for DGF. A 49-point scoring system of donor risk was established for DGF prediction and exhibited a superior degree of discrimination. External validation of DGF prediction revealed area under the receiver-operating characteristic (AUC) curves of 0.7552. Conclusions Our study determined the deceased donor risk factors related to DGF after renal transplantation pertinent to the Chinese cohort. The scoring system developed here had superior diagnostic significance and consistency and can be used by clinicians to make evidence-based decisions on the quality of kidneys from deceased donors and guide renal transplantation therapy.
基金：
Major Clinical Research Projects of the First Affiliated Hospital of Xi'an Jiaotong University [XJTU1AF-CRF-2015-005, XJTU1AF-CRF-2018-026]
第一作者机构：[a]The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China[b]Institute of Organ Transplantation of Xi’an Jiaotong University,Xi’an, China[*a]Department of Renal Transplantation, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China
通讯作者：
通讯机构：[a]The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China[b]Institute of Organ Transplantation of Xi’an Jiaotong University,Xi’an, China[*a]Department of Renal Transplantation, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China
推荐引用方式(GB/T 7714)：
Wujun Xue,Changxi Wang,Jianghua Chen,et al.A prediction model of delayed graft function in deceased donor for renal transplant: a multi-center study from China[J].RENAL FAILURE.2021,43(1):520-529.doi:10.1080/0886022X.2021.1895838.
APA：
Wujun Xue,Changxi Wang,Jianghua Chen,Xuyong Sun,Xiaotong Wu...&Yingxin Fu.(2021).A prediction model of delayed graft function in deceased donor for renal transplant: a multi-center study from China.RENAL FAILURE,43,(1)
MLA：
Wujun Xue,et al."A prediction model of delayed graft function in deceased donor for renal transplant: a multi-center study from China".RENAL FAILURE 43..1(2021):520-529
