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Two cases of hand, foot, and mouth disease caused by enterovirus A71 after vaccination.

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机构： [1]Institute of Paediatrics, The Kunming Children’s Hospital of Kunming Medical University, Kunming, PR China [2]Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, PR China [3]Yunnan Key Laboratory of Children’s Major Disease Research, Kunming, PR China [4]Department of Laboratory, The Kunming Children’s Hospital, Kunming, PR China [5]Department of Paediatrics, The First People’s Hospital of Yunnan Province, Kunming, PR China [6]Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, PR China

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Enterovirus A71 (EVA71) is often identified as one of the main pathogens that lead to the vast majority of hand, foot, and mouth disease (HFMD) cases. In China, the proportion of HFMD cases caused by EVA71 decreases significantly after EVA71 vaccination; however, infection with EVA71 can still occur after vaccination. The complete genomic sequencesof EVA71-KM18A and KM18B (from two rare cases of EVA71 infection after vaccination) were obtained and performed phylogenetic, nucleotide mutation,recombinant analyses, and comparative analysis of amino acid mutations. Phylogenetic analysis determined that the EVA71 strains belong to the C4a subgenotype. The KM18A and KM18B strains were highly similar to the vaccine strains. For the KM18B strain, there were some obvious homologous recombination signals in 5'non-coding region, region 2A, region 2C, and region 3D. Amino acid mutations were observed at SP55 (position 729,) and 71-6 (position 500,) conformational neutralizing epitopes of KM18A and KM18B strains. These amino acid mutations maybe affected the SP55 and the 71-6 conformational neutralizing epitopes and change their spatial conformation, thereby weakening the effect of the vaccine. Copyright © 2021. Published by Elsevier Ltd.

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出版当年[2021]版：

大类 | 3 区医学

小类 | 3 区传染病学

最新[2023]版：

大类 | 2 区

医学

小类 | 2 区传染病学

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出版当年[2020]版：

Q2 INFECTIOUS DISEASES

最新[2023]版：

Q1 INFECTIOUS DISEASES

影响因子： 4.8 最新[2023版] 5 最新五年平均 3.623 出版当年[2020版] 4.01 出版当年五年平均 3.202 出版前一年[2019版] 12.073 出版后一年[2021版]

第一作者：

第一作者机构： [1]Institute of Paediatrics, The Kunming Children’s Hospital of Kunming Medical University, Kunming, PR China [2]Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, PR China

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通讯作者：

通讯机构： [1]Institute of Paediatrics, The Kunming Children’s Hospital of Kunming Medical University, Kunming, PR China [2]Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, PR China [3]Yunnan Key Laboratory of Children’s Major Disease Research, Kunming, PR China [6]Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, PR China [*1]The Affiliated Children’s Hospital of Kunming Medical University, 288 Qian Xin Road, Kunming, Yunnan Province 650228, PR China. [*2]Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, 935 Jiao Ling Road, Kunming, Yunnan Province 650118, PR China.

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