机构：[1]Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, People’s Republic of China[2]Kunming Children’s Hospital, The Affiliated Children’s Hospital of Kunming Medical University[3]Institute of Pediatric Disease Research in Yunnan, Kunming, People’s Republic of China[4]Yunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Diseases, Kunming, People’s Republic of China[5]Yunnan Key Laboratory of Children’s Major Disease Research, Kunming, People’s Republic of China[6]State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China[8] Institute of Pediatric Disease Research in Yunnan, Kunming 650228, People’s Republic of China[9] Qiangming Sun
Enterovirus A71 (EV-A71) inactivated vaccines have been widely inoculated among children in Kunming City after it was approved. However, there was a large-scale outbreak of Enteroviruses (EVs) infection in Kunming, 2018.The epidemiological characteristics of HFMD and EVs were analyzed during 2008 to 2018, which are before and three years after EV-A71 vaccine starting to use. The changes of infection spectrum were also investigated, especially for severe HFMD in 2018.The incidence of EV-A71 decreased dramatically after EV-A71 vaccine starting use. The proportion of non CV-A16/EV-A71 EVs positive patients raised up to 77.17% to 85.82%, while, EV-A71 and CV-A16 only accounted for 3.41% to 7.24% and 6.94% to 19.42% in 2017 and 2018. CV-A6 was the most important causative agent in all clinical symptoms (Severe HFMD, HFMD, Herpangina and fever), accounting from 42.13% to 62.33%. EV-A71 only account for 0.36% to 2.05%. In sever HFMD, CV-A6 (62.33%), CV-A10 (11.64%), CV-A16 (10.96%) were the major causative agent in 2018.EV-A71 inactivated vaccine has a good protective effect against EV-A71 and induced EVs infection spectrum changefully. EV-A71 vaccine has no or insignificant cross-protection effect on CV-A6, CV-A10 and CV-A16. Herein, developing 4-valent combined vaccines is urgently needed.
基金：
This work was supported by the Foundation of the CAMS
Initiative for Innovative Medicine [grant number 2016-
I2M-1-019]; the National Natural Science Foundation of
China [grant number 31970868]; the Natural Science Foundation
of Yunnan [grant number 2019ZF004]; the Foundation
of the Yunnan Education Science and Technology
Research [grant number 2018JS241] and Foundation of
the Kunming Science and Technology Research [grant
number 2017-1-S-15381].
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|2 区医学
小类|2 区免疫学2 区传染病学2 区微生物学
最新[2023]版：
大类|2 区医学
小类|1 区传染病学2 区免疫学2 区微生物学
第一作者：
第一作者机构：[1]Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, People’s Republic of China[2]Kunming Children’s Hospital, The Affiliated Children’s Hospital of Kunming Medical University[3]Institute of Pediatric Disease Research in Yunnan, Kunming, People’s Republic of China[5]Yunnan Key Laboratory of Children’s Major Disease Research, Kunming, People’s Republic of China
共同第一作者：
通讯作者：
通讯机构：[1]Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, People’s Republic of China[2]Kunming Children’s Hospital, The Affiliated Children’s Hospital of Kunming Medical University[3]Institute of Pediatric Disease Research in Yunnan, Kunming, People’s Republic of China[4]Yunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Diseases, Kunming, People’s Republic of China[5]Yunnan Key Laboratory of Children’s Major Disease Research, Kunming, People’s Republic of China[*1]Kunming Children’s Hospital, The Affiliated Children’s Hospital of Kunming Medical University[*2]Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, People’s Republic of China
推荐引用方式(GB/T 7714)：
Jiang Hongchao,Zhang Zhen,Rao Qing,et al.The epidemiological characteristics of Enterovirus infection before and after the use of Enterovirus 71 inactivated vaccine in Kunming, China.[J].Emerging microbes & infections.2021,1-32.doi:10.1080/22221751.2021.1899772.
APA：
Jiang Hongchao,Zhang Zhen,Rao Qing,Wang Xiaodan,Wang Meifen...&Sun Qiangming.(2021).The epidemiological characteristics of Enterovirus infection before and after the use of Enterovirus 71 inactivated vaccine in Kunming, China..Emerging microbes & infections,,
MLA：
Jiang Hongchao,et al."The epidemiological characteristics of Enterovirus infection before and after the use of Enterovirus 71 inactivated vaccine in Kunming, China.".Emerging microbes & infections .(2021):1-32
医学