机构：[1]Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China.[2]Kunming Key Laboratory of Children Infection and Immunity, Yunnan Institute of Pediatrics, Kunming Children's Hospital, Kunming 650228, Yunnan, China.[3]Department of Urology, Guangzhou First People's Hospital, the Second Affiliated Hospital of South China University of Technology, Guangzhou 510180, Guangdong, China.[4]Department of Clinical Laboratory, Molecular Epidemiology Laboratory, Harbin Medical University Cancer Hospital, Harbin 150040, Heilongjiang, China.
Wilms tumor (WT) is the most prevalent urologic malignancy in childhood. Nonetheless, the genetic factors underlying WT remain largely unknown. The miR-423 rs6505162 C>A polymorphism is associated with the susceptibility to numerous cancers; however, no investigations have been conducted on its association with WT. To evaluate the correlation between the miR-423 rs6505162 C>A polymorphism and WT risk in Chinese children, we genotyped this polymorphism using the Taqman method in 145 cases and 531 cancer-free controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the strength of the association. The results showed that the rs6505162 CA genotype was associated with decreased susceptibility to WT (CA versus CC: adjusted OR=0.65, 95% CI=0.42-0.99, P=0.047). In the stratified analysis, we found that CA/AA genotypes conferred a significantly decreased overall risk of WT in children younger than 18 months (adjusted OR=0.30, 95% CI=0.14-0.63, P=0.002) and those with clinical stage I+II WT (adjusted OR=0.42, 95% CI=0.20-0.85, P=0.017) when compared with CC genotype. In summary, the miR-423 rs6505162 C>A polymorphism may negatively modify WT susceptibility in Chinese children. Our findings should be validated in larger studies involving other ethnicities.
基金：
This study was supported by grants from the
Science and Technology Project of Guangzhou (No:
201804010037), the Pearl River S&T Nova Program of
Guangzhou (No: 201710010086) and the State Clinical
Key Specialty Construction Project (Paediatric
Surgery) 2013 (No: GJLCZD1301).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|3 区医学
小类|3 区肿瘤学
最新[2023]版：
大类|3 区医学
小类|4 区肿瘤学
第一作者：
第一作者机构：[1]Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China.
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Pediatric Urology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China[*2]Department of Pediatric Surgery, Guangzhou Institute of Pediatrics,Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, 9 Jinsui Road, Guangzhou 510623, Guangdong, China
推荐引用方式(GB/T 7714)：
Fu Wen,Li Li,Xiong Si-Wei,et al.miR-423 rs6505162 C>A polymorphism contributes to decreased Wilms tumor risk[J].Journal of Cancer.2018,9(14):2460-2465.doi:10.7150/jca.24916.
APA：
Fu Wen,Li Li,Xiong Si-Wei,Zhang Tiesong,Jia Wei...&Liu Guo-Chang.(2018).miR-423 rs6505162 C>A polymorphism contributes to decreased Wilms tumor risk.Journal of Cancer,9,(14)
MLA：
Fu Wen,et al."miR-423 rs6505162 C>A polymorphism contributes to decreased Wilms tumor risk".Journal of Cancer 9..14(2018):2460-2465
