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Developing of focal ischemia in the hippocampus or the amygdala reveals a regional compensation rule for fear memory acquisition(Open Access)

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机构： [1]Kunming Institute of Zoology and Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences (CAS), Kunming 650223, China, [2]Department of Biochemistry and Molecular Biology, College of Basic Medicine, Kunming Medical University, Kunming, 650500, China, [3]Department of Nuclear Medicine, First People’s Hospital of Yunnan Province, and Key Laboratory of Medical Imaging, Kunming University of Science and Technology, Kunming 650032, China, [4]Wuhan Institute of Physics and Mathematics, CAS, Wuhan 430071, China, [5]Department of Neurobiology and Ethology, and Department of Psychology, University of Haifa, Haifa 3498838, Israel, [6]The Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China

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关键词： Amygdala Circuits Fear memory Hippocampus Ischemia

摘要：

Circuit compensation is often observed in patients with acute ischemic stroke, suggesting the importance of the interaction between brain regions. Also, contextual fear memory is an association between multisensory contexts and fearful stimuli, for which the interaction between the hippocampus and the amygdala is believed to be critical. To understand how focal ischemia in one region could influence the other region, we used a modified photo-thrombosis to induce focal ischemia in the hippocampus or the amygdala or both in freely-moving rats. We found that the learning curve and short-term memory (STM) were not affected in the rats although focal ischemia was induced 5 h before learning in either the hippocampus or the amygdala; these were impaired by the induction of ischemia in both the regions. Furthermore, the learning curve and STM were impaired when ischemia was induced 24 h before learning in either the hippocampus or the amygdala when the synaptic transmission was altered in one region because of ischemia in the other region. These results suggest that the circuit compensation between the hippocampus and the amygdala is critical for fear memory acquisition. © 2021 Yu et al.

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出版当年[2021]版：

大类 | 3 区医学

小类 | 3 区神经科学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区神经科学

第一作者：

第一作者机构： [1]Kunming Institute of Zoology and Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences (CAS), Kunming 650223, China, [6]The Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China

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通讯作者：

通讯机构： [1]Kunming Institute of Zoology and Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences (CAS), Kunming 650223, China, [*1]Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, MA.

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Developing of focal ischemia in the hippocampus or the amygdala reveals a regional compensation rule for fear memory acquisition(Open Access)

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