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Alterations in the gut virome in obesity and type 2 diabetes mellitus.

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收录情况： ◇ SCIE

作者：
Keli Yang[1,2,3] * ; Junkun Niu[4] * ; Tao Zuo[1,2,3,7] ; Yang Sun[4] ; Zhilu Xu[1,2,3,7] ; WhitneyTang[1,2,3,7] ; Qin Liu[1,2,3,7] ; Jingwan Zhang[1,2,3,7] ; Enders KW Ng[3,5] ; Simon KH Wong[3,5] ; YunKit Yeoh[1,6,7] ; Paul KS Chan[1,6,7] ; Francis KL Chan[1,2,3,7] ; Yinglei Miao[4,*2] ; Siew C Ng[1,2,3,7,*1] ;
机构： [1]Center for Gut Microbiota Research, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China. [2]Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China. [3]Institute of Digestive Disease, State Key Laboratory of Digestive Diseases, LKS Institute of Health Science, The Chinese University of Hong Kong, Hong Kong, China. [4]Department of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Yunnan Institute of Digestive Disease, Kunming, Yunnan Province, China [5]Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China. [6]Department of Microbiology, The Chinese University of Hong Kong, Hong Kong, China. [7]Microbiota I-Center (MagIC) Limited, Hong Kong, China
出处：
DOI： 10.1053/j.gastro.2021.06.056
ISSN：

摘要：
Obesity and type 2 diabetes mellitus (T2DM) are associated with changes in the gut bacterial composition, but little is known about the role of the viral community (virome) in disease development. This study aims to characterize the gut virome alterations in obese subjects with or without T2DM.128 obese subjects (Body Mass Index (BMI) ≥28Kg/m2) and 101 lean controls (BMI ≥ 18.5 and < 23 Kg/m2) were recruited from two regions in China (Hong Kong: HK; Kunming: KM). Fecal virome and bacteriome were profiled by shotgun metagenomic sequencing. Gut virome, bacteriome and viral-bacterial correlations were compared between obese subjects and lean controls.Obese subjects especially those with T2DM (ObT2) had a decreased gut viral richness and diversity compared with lean controls in the HK cohort (p < .05), while no significant differences were observed in the KM cohort. Eleven viruses, including Escherichia phage, Geobacillus phage and Lactobacillus phage were enriched in obese subjects (q < .1). Besides, seventeen differentially abundant viruses were identified between ObT2 and lean controls (q < .1). Further ecological analysis revealed that intensive trans-kingdom correlations between viruses and bacteria observed in lean controls were significantly decreased in ObT2 subjects (p < .001).Obesity is characterized by altered viral taxonomic composition and weakened viral-bacterial correlations compared with lean controls. Accompanied with T2DM may aggravate the obesity-associated virus signatures, signifying that gut virome may play an important role in the development of obesity and T2DM. Geographic factors also contributed to the variations of gut virome in obesity and T2DM.Copyright © 2021 AGA Institute. Published by Elsevier Inc. All rights reserved.

基金：
This work is supported by InnoHK, The Government of Hong Kong, Special Administrative Region of the People’s Republic of China; National Natural Science Foundation of China (U1802282,81960108）; Applied Basic Research Projects of Yunnan Province [2019FE001(036)]; Medicine Leading Talent of Health and Family Planning Commission of Yunnan Province (L-201607).
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外文
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中科院(CAS)分区：
出版当年[2021]版：
大类 | 1 区 医学
小类 | 1 区 胃肠肝病学
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 胃肠肝病学
JCR分区：
出版当年[2020]版：
Q1 GASTROENTEROLOGY & HEPATOLOGY
最新[2023]版：
Q1 GASTROENTEROLOGY & HEPATOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者机构： [1]Center for Gut Microbiota Research, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China. [2]Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China. [3]Institute of Digestive Disease, State Key Laboratory of Digestive Diseases, LKS Institute of Health Science, The Chinese University of Hong Kong, Hong Kong, China.
共同第一作者：
通讯作者：
通讯机构： [1]Center for Gut Microbiota Research, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China. [2]Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China. [3]Institute of Digestive Disease, State Key Laboratory of Digestive Diseases, LKS Institute of Health Science, The Chinese University of Hong Kong, Hong Kong, China. [4]Department of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Yunnan Institute of Digestive Disease, Kunming, Yunnan Province, China [7]Microbiota I-Center (MagIC) Limited, Hong Kong, China [*1]Department of Medicine and Therapeutics, The Chinese University of Hong Kong [*2]Department of Gastroenterology, The First Affiliated Hospital of Kunming Medical University
推荐引用方式(GB/T 7714)：
Keli Yang,Junkun Niu,Tao Zuo,et al.Alterations in the gut virome in obesity and type 2 diabetes mellitus.[J].GASTROENTEROLOGY.2021,161(4):1257-+.doi:10.1053/j.gastro.2021.06.056.
APA：
Keli Yang,Junkun Niu,Tao Zuo,Yang Sun,Zhilu Xu...&Siew C Ng.(2021).Alterations in the gut virome in obesity and type 2 diabetes mellitus..GASTROENTEROLOGY,161,(4)
MLA：
Keli Yang,et al."Alterations in the gut virome in obesity and type 2 diabetes mellitus.".GASTROENTEROLOGY 161..4(2021):1257-+

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