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Association between plasma neurofilament light chain levels and cognitive function in patients with Parkinson's disease.

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收录情况： ◇ SCIE

作者：
Zhu Yongyun[1] * ; Yang Baiyuan[2] * ; Wang Fang[1] * ; Liu Bin[1] ; Li Kelu[1] ; Yin Kangfu[1] ; Yin Wei Fang[1] ; Zhou Chuanbin[1] ; Tian Sijia[3] ; Ren Hui[1] ; Pang Ailan[4] ; Yang Xinglong[1] ;
机构： [1]Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province 650032, PR China [2]Department of Neurology, Seventh People's Hospital of Chengdu, Chengdu, Sichuan Province 690041, PR China [3]Department of Neurology, West China Hospital, Sichuan University, PR China [4]Department of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province 650032, PR China
出处：
DOI： 10.1016/j.jneuroim.2021.577662
ISSN：

摘要：
This study investigated the potential association between levels of plasma neurofilament light chain (NfL) and cognitive function in patients suffering from Parkinson's disease (PD) in P.R. China.We collected a total of 168 participants (130 PD patients and 38 healthy controls),and evaluated the relationship of plasma NfL levels with cognitive dysfunction in PD patients. Our results shown that plasma NfL levels increased with an increase in cognitive impairment across the three groups of PD patients: PD with normal cognition (PD-NC), 17.9 ± 8.9 pg/ml; PD with mild cognitive impairment (PD-MCI),21.9 ± 10.3 pg/ml; and PD dementia (PDD), 35.7 ± 21.7 pg/ml. Higher MMSE scores were associated with lower plasma NfL levels (r = -0.49, 95% CI -0.61 to -0.34, p < 0.0001). Our results associating plasma NfL levels with cognitive dysfunction in PD are consistent with previous studies carried out in several countries/district, based on our meta-analysis.Copyright © 2021 Elsevier B.V. All rights reserved.

基金：
This work was supported by the National Natural Science Foundation of China [81960242,81660247], the Chengdu Medical College and Chengdu Seventh People's Hospital Joint Scientific Research Fund [2020LHJYZD-02], the Yunnan Applied Basic Research Project [2019FE001-048, 202001AT070001], the Yunnan Provincial Health Science and Technology Project [2018NS0102], and the Applied Basic Research Fund of The Diagnosis and Treatment Center of Neurological Diseases in Yunnan Province [ZX2019-03-05].
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外文
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中科院(CAS)分区：
出版当年[2021]版：
大类 | 3 区 医学
小类 | 3 区 神经科学 4 区 免疫学
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 免疫学 4 区 神经科学
JCR分区：
出版当年[2020]版：
Q3 IMMUNOLOGY Q3 NEUROSCIENCES
最新[2023]版：
Q2 NEUROSCIENCES Q3 IMMUNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者机构： [1]Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province 650032, PR China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Zhu Yongyun,Yang Baiyuan,Wang Fang,et al.Association between plasma neurofilament light chain levels and cognitive function in patients with Parkinson's disease.[J].JOURNAL OF NEUROIMMUNOLOGY.2021,358:doi:10.1016/j.jneuroim.2021.577662.
APA：
Zhu Yongyun,Yang Baiyuan,Wang Fang,Liu Bin,Li Kelu...&Yang Xinglong.(2021).Association between plasma neurofilament light chain levels and cognitive function in patients with Parkinson's disease..JOURNAL OF NEUROIMMUNOLOGY,358,
MLA：
Zhu Yongyun,et al."Association between plasma neurofilament light chain levels and cognitive function in patients with Parkinson's disease.".JOURNAL OF NEUROIMMUNOLOGY 358.(2021)

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