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Construction and analysis of the abnormal lncRNA-miRNA-mRNA network in hypoxic pulmonary hypertension.

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收录情况： ◇ SCIE ◇ 预警期刊

作者：
Jie Liu[1] * ; Yishu Deng[2] ; Zeqin Fan[2] ; Shuanglan Xu[2] ; Li Wei[2] ; Xiaoxian Huang[2] ; Xiqian Xing[2] ; Jiao Yang[3] ;
机构： [1]Department of Respiratory Medicine, The Fourth Affiliated Hospital of Kunming Medical University, Kunming 650021, Yunnan, China [2]Department of Respiratory Medicine, The Affiliated Hospital of Yunnan University, The Second People’s Hospital of Yunnan Province, Kunming 650021, Yunnan, China [3]First Department of Respiratory Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, China
出处：
DOI： 10.1042/BSR20210021
ISSN：

摘要：
The incidence of hypoxic pulmonary hypertension (HPH) is increasing. Accumulating evidence suggests that long noncoding RNAs (lncRNAs) play an important role in HPH, but the functions and mechanism have yet to be fully elucidated. In the present study, we established a HPH rat model with 8 h of hypoxia exposure (10% O2) per day for 21 days. High-throughput sequencing identified 60 differentially expressed (DE) lncRNAs, 20 DE miRNAs and 695 DE mRNAs in rat lung tissue. qRT-PCR verified the accuracy of the results. The DE mRNAs were significantly enriched in immune response, inflammatory response, leukocyte migration, cell cycle, cellular response to interleukin-1, IL-17 signalling pathway, cytokine-cytokine receptor interaction and Toll-like receptor signalling pathway. According to the theory of competing endogenous RNA (ceRNA) networks, lncRNA-miRNA-mRNA network was constructed by Cytoscape software, 16 miRNAs and 144 mRNAs. The results suggested that seven DE lncRNAs (Ly6l, AABR07038849.2, AABR07069008.2, AABR07064873.1, AABR07001382.1, AABR07068161.1 and AABR07060341.2) may serve as molecular sponges of the corresponding miRNAs and play a major role in HPH.© 2021 The Author(s).

基金：
This research was supported by a grant from the National Natural Science Foundation of China [grant numbers 81760015 and 82160016]; the “Special and Joint Program” of Yunnan Provincial Science and Technology Department and Kunming Medical University [grant number 2018FE001 (-206)]; the Yunnan Health Training Project of High-level Talents [grant number H-2018095]; the Young Academic and Technical Leaders of Yunnan Province [grant number 2017HB053]; and Famous Doctors of High-level Talent Training Support Program of Yunnan Province.
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外文
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PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 3 区 生物
小类 | 4 区 生化与分子生物学 4 区 细胞生物学
最新[2023]版：
大类 | 3 区 生物学
小类 | 3 区 生化与分子生物学 4 区 细胞生物学
JCR分区：
出版当年[2020]版：
Q3 CELL BIOLOGY Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
最新[2023]版：
Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q2 CELL BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者机构： [1]Department of Respiratory Medicine, The Fourth Affiliated Hospital of Kunming Medical University, Kunming 650021, Yunnan, China
通讯作者：
推荐引用方式(GB/T 7714)：
Jie Liu,Yishu Deng,Zeqin Fan,et al.Construction and analysis of the abnormal lncRNA-miRNA-mRNA network in hypoxic pulmonary hypertension.[J].BIOSCIENCE REPORTS.2021,41(8):doi:10.1042/BSR20210021.
APA：
Jie Liu,Yishu Deng,Zeqin Fan,Shuanglan Xu,Li Wei...&Jiao Yang.(2021).Construction and analysis of the abnormal lncRNA-miRNA-mRNA network in hypoxic pulmonary hypertension..BIOSCIENCE REPORTS,41,(8)
MLA：
Jie Liu,et al."Construction and analysis of the abnormal lncRNA-miRNA-mRNA network in hypoxic pulmonary hypertension.".BIOSCIENCE REPORTS 41..8(2021)

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