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Phenobarbital versus valproate for generalized convulsive status epilepticus in adults (2): A multicenter prospective randomized controlled trial in China (China 2-P vs. V).

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机构： [1]Neurocritical Care Committee of the Chinese Society of Neurology (CSN/NCC) and the Neurocritical Care Committee of the China Neurologist Association (CNA/NCC), Neurointensive Care Unit, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [2]Neurointensive Care Unit, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [3]Department of Neurology, Nanfang Hospital of Southern Medical University, Guangzhou 510515, China [4]Department of Neurology, The Affiliated Hospital of Kunming University of Science and Technology, Kunming 654100, China [5]Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China [6]Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi’an, 710032, China [7]Department of Neurology, Zhongshan Hospital, Xiamen University, Xiamen, 200032, China

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A multicenter study of phenobarbital versus valproate (i.e., the China 2-P vs. V study) was conducted to compare the efficacy and safety of phenobarbital and valproate for generalized convulsive status epilepticus (SE) in a multicenter trial design.Three improvements (uniform intravenous pumping, pump speed adjustment according to adverse events and blood drug level monitoring) over a previous study were made regarding an intravenous regimen of phenobarbital and valproate in a multicenter, prospective, randomized, controlled study. Long-term electroencephalography (EEG) monitoring was performed after initial drug treatment. Termination, relapse, adverse event and poor prognosis rates in patients with generalized convulsive status epilepticus (GCSE) were compared.The rate of GCSE termination within one hour were significantly higher in the phenobarbital group (33 cases) than in the valproate group (36 cases) (84.8 % vs. 63.9 %, P = 0.048), but the rates of nontermination of EEG epileptic discharge within one hour were similar between the two groups (12.1 % vs. 8.3 %, P = 0.702). The relapse and adverse event rates were not significantly different between groups, but 3 hypoventilation events and 1 hypotension event occurred in the phenobarbital group compared to 0 in the valproate group. There were no cases of epileptiform EEG discharge relapse in the phenobarbital group, compared to 1 case in the valproate group.The phenobarbital regimen evaluated in this study has a higher GCSE termination rate than the valproate regimen, indicating that the former is suitable for countries, regions and individuals with limited access to new antiepileptic drugs or limited economic means.Copyright © 2021 Elsevier B.V. All rights reserved.

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出版当年[2021]版：

大类 | 4 区医学

小类 | 4 区临床神经病学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区临床神经病学

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出版当年[2020]版：

Q3 CLINICAL NEUROLOGY

最新[2023]版：

Q3 CLINICAL NEUROLOGY

影响因子： 2 最新[2023版] 2.3 最新五年平均 3.045 出版当年[2020版] 3.143 出版当年五年平均 2.208 出版前一年[2019版] 2.991 出版后一年[2021版]

第一作者：

第一作者机构： [1]Neurocritical Care Committee of the Chinese Society of Neurology (CSN/NCC) and the Neurocritical Care Committee of the China Neurologist Association (CNA/NCC), Neurointensive Care Unit, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [*1]Neurointensive Care Unit, Xuanwu Hospital, Capital Medical University, Beijing 100053, China

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通讯作者：

通讯机构： [1]Neurocritical Care Committee of the Chinese Society of Neurology (CSN/NCC) and the Neurocritical Care Committee of the China Neurologist Association (CNA/NCC), Neurointensive Care Unit, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [*1]Neurointensive Care Unit, Xuanwu Hospital, Capital Medical University, Beijing 100053, China

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