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Diagnosis of Lung Cancer by ATR-FTIR Spectroscopy and Chemometrics.

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机构： [1]School of Physics and Electronic Information, Yunnan Normal University, Kunming, China. [2]Department of Thoracic Surgery, The First People's Hospital of Yunnan Province, Kunming, China. [3]Department of Clinical Laboratory, Affiliated Hospital of Zunyi Medical University, Zunyi, China. [4]Department of Internal Medicine, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, China. [5]School of Physics and Electronic Engineering, Qujing Normal University, Qujing, China.

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Lung cancer is the leading cause of cancer-related death in the world. Early diagnosis has great significance for the survival of patients with lung cancer. In this paper, attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy combined with chemometrics was used to study the serum samples from patients with lung cancer and healthy people. The results of spectral band area comparison showed that the concentrations of protein, lipid and nucleic acids molecules in serum of patients with lung cancer were increased compared with those in healthy people. The original spectra were preprocessed to improve the accuracy of principal component regression (PCR) and partial least squares-discriminant analysis (PLS-DA) models. PLS-DA results for first derivative spectral data in nucleic acids (1250-1000cm-1) band showed 80% sensitivity, 91.89% specificity and 87.10% accuracy with high R c 2 of 0.8949 and R v 2 of 0.8153, low RMSEC of 0.3136 and RMSEV of 0.4180. It is shown that ATR-FTIR spectroscopy combined with chemometrics might be developed as a simple method for clinical screening and diagnosis of lung cancer.Copyright © 2021 Yang, Ou, Qian, Yang, Bai, Yang, Shi and Liu.

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出版当年[2021]版：

大类 | 2 区医学

小类 | 3 区肿瘤学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区肿瘤学

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出版当年[2020]版：

Q2 ONCOLOGY

最新[2023]版：

Q2 ONCOLOGY

影响因子： 3.5 最新[2023版] 4 最新五年平均 6.244 出版当年[2020版] 6.264 出版当年五年平均 4.848 出版前一年[2019版] 5.738 出版后一年[2021版]

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第一作者机构： [1]School of Physics and Electronic Information, Yunnan Normal University, Kunming, China.

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