个人中心| | 帮助
高级检索
当前位置： 首页 > 详情页

The role of TRPV channels in osteoporosis.

| 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Liu Na[1] * ; Lu Weiwei[2] * ; Dai Xiaolin[2] ; Qu Xiaowen[3] ; Zhu Chongtao[3] ;
机构： [1]Department of Anesthesiology, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, China [2]Medical School, Kunming University of Science and Technology, Kunming 650500, China [3]Laser Medical Center, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, No. 159 JinBi Road, Kunming 650032, China
出处：
DOI： 10.1007/s11033-021-06794-z
ISSN：

摘要：
As the world's population ages, the treatment of osteoporosis is a major problem to be addressed. The cause of osteoporosis remains unclear. Ca2+ is not only an important component of bones but also plays a key role in osteoporosis treatment. Transient receptor potential vanilloid (TRPV) channels are one of the TRP channel families that is widely distributed in various organs, playing an important role in the physiological regulation of the human body. Bone formation and bone absorption may require Ca2+ transport via TRPV channels. It has been proven that the TRPV subtypes 1, 2, 4, 5, 6 (TRPV1, TRPV2, TRPV4, TRPV5, TRPV6) may affect bone metabolism balance through selective regulation of Ca2+. They significantly regulate osteoblast/osteoclast proliferation, differentiation and function. The purpose of this review is to explore the mechanisms of TRPV channels involved in regulation of the differentiation of osteoblasts and osteoclasts, as well as to discuss the latest developments in current researches, which may provide new clues and directions for an in-depth study of osteoporosis and other related bone metabolic diseases.© 2021. The Author(s), under exclusive licence to Springer Nature B.V.

基金：
This work was supported by National Key Research and Development Project (No.2017YFB0403801); The Joint Special Program of Science and Technology Department of Yunnan Province and Kunming Medical University for applied basic research [No.2019FE001(-111)]; Application base project of Yunnan Science and Technology Department (No.2019FB097); Yunnan health training project of high level talents (No.D-2018005);Yunnan Fundamental Research Key Projects (No. 202101AS070046);Yunnan High-level Scientific and Technological Talent Platform Plan (No. 202105AC160064).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 4 区 生物学
小类 | 4 区 生化与分子生物学
最新[2023]版：
大类 | 4 区 生物学
小类 | 4 区 生化与分子生物学
JCR分区：
出版当年[2021]版：
Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
最新[2023]版：
Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Department of Anesthesiology, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Liu Na,Lu Weiwei,Dai Xiaolin,et al.The role of TRPV channels in osteoporosis.[J].MOLECULAR BIOLOGY REPORTS.2022,49(1):577-585.doi:10.1007/s11033-021-06794-z.
APA：
Liu Na,Lu Weiwei,Dai Xiaolin,Qu Xiaowen&Zhu Chongtao.(2022).The role of TRPV channels in osteoporosis..MOLECULAR BIOLOGY REPORTS,49,(1)
MLA：
Liu Na,et al."The role of TRPV channels in osteoporosis.".MOLECULAR BIOLOGY REPORTS 49..1(2022):577-585

资源点击量：82490 今日访问量：0 总访问量：681 更新日期：2025-01-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 云南省第一人民医院 技术支持：重庆聚合科技有限公司 地址：云南省昆明市西山区金碧路157号