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Development of gut microbiota along with its metabolites of preschool children.

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机构： [1]Department of Pediatrics, the First Affiliated Hospital of Kunming MedicalUniversity, No. 295, Xichang Road, Xishan District, Kunming 650032, China [2]Department of Statistics, School of Public Health, Kunming Medical University,Kunming 650000, China [3]Yunnan Center for Disease Control and Prevention,158 Dongsi Street, Xishan District, Kunming 650022, Yunnan, China [4]Department of Clinical Laboratory, the First Affiliated Hospital of KunmingMedical University, Kunming 650032, China.

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To reveal the changes of intestinal microbial abundance and composition, as well as the microbiota metabolic levels of bile acids and short chain fatty acids of healthy preschool children during their growth.Feces of 120 healthy newborns and 150 healthy children aged 6 months to 6 years were collected. Then the composition of intestinal flora was analyzed by 16S rRNA, and the contents of bile acids and short chain fatty acids in feces were detected by LC-MS and GS methods, respectively.The composition and function of intestinal microflora were not stable in neonatal period but significantly improved at 6 months after birth, and gradually stabilized and tended to adult-like formation after 2-3 years old. The levels of short chain fatty acids and secondary bile acids were consistent with the development of gut microbiota.The age of 6 months may be a critical period for the development of intestinal microflora in children.© 2022. The Author(s).

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出版当年[2022]版：

大类 | 3 区医学

小类 | 3 区儿科

最新[2023]版：

大类 | 3 区医学

小类 | 3 区儿科

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出版当年[2021]版：

Q3 PEDIATRICS

最新[2023]版：

Q2 PEDIATRICS

影响因子： 2 最新[2023版] 2.4 最新五年平均 2.567 出版当年[2021版] 3.002 出版当年五年平均 2.125 出版前一年[2020版] 2.4 出版后一年[2022版]

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第一作者机构： [1]Department of Pediatrics, the First Affiliated Hospital of Kunming MedicalUniversity, No. 295, Xichang Road, Xishan District, Kunming 650032, China

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