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YB-1 is a positive regulator of KLF5 transcription factor in basal-like breast cancer.

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收录情况： ◇ SCIE

作者：
Dewei Jiang [1,2] * ; Ting Qiu[1,2] * ; Junjiang Peng[1] * ; Siyuan Li[1] * ; Tala[3] ; Wenlong Ren[1,4] ; Chuanyu Yang[1] ; Yi Wen[1] ; Chuan-Huizi Chen[5] ; Jian Sun[1,2] ; Yingying Wu[6] ; Rong Liu[7] ; Jun Zhou [3] ; Kongming Wu [8] ; Wen Liu [9] ; Xiaoyun Mao[10] ; Zhongmei Zhou[1] ; Ceshi Chen [1,2,11] ;
机构： [1]Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academyof Sciences, Kunming, China [2]Kunming College of Lifesciences, University of Chinese Academy Sciences, Kunming, China [3]State Key Laboratory of Medicinal ChemicalBiology, College of Life Sciences, Nankai University, Tianjin, China [4]College of Life Sciences, China University of Science and Technology, Hefei, Anhui, China [5]School ofChinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, China [6]The First Affiliated Hospital, Kunming Medical University, Kunming, China [7]The FirstAffiliated Hospital, Peking University, Beijing, China [8]Department of Oncology, Tongji Hospital of Tongji Medical College of Huazhong University of Science andTechnology, Wuhan, China [9]School of Pharmaceutical Science, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiamen, China [10]Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China [11]KIZ-CUHK Joint Laboratory of Bioresources and MolecularResearch in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
出处：
DOI： 10.1038/s41418-021-00920-x
ISSN：

摘要：
Y-box binding protein 1 (YB-1) is a well-known oncogene highly expressed in various cancers, including basal-like breast cancer (BLBC). Beyond its role as a transcription factor, YB-1 is newly defined as an epigenetic regulator involving RNA 5-methylcytosine. However, its specific targets and pro-cancer functions are poorly defined. Here, based on clinical database, we demonstrate a positive correlation between Kruppel-like factor 5 (KLF5) and YB-1 expression in breast cancer patients, but a negative correlation with that of Dachshund homolog 1 (DACH1). Mechanistically, YB-1 enhances KLF5 expression not only through transcriptional activation that can be inhibited by DACH1, but also by stabilizing KLF5 mRNA in a RNA 5-methylcytosine modification-dependent manner. Additionally, ribosomal S6 kinase 2 (RSK2) mediated YB-1 phosphorylation at Ser102 promotes YB-1/KLF5 transcriptional complex formation, which co-regulates the expression of BLBC specific genes, Keratin 16 (KRT16) and lymphocyte antigen 6 family member D (Ly6D), to promote cancer cell proliferation. The RSK inhibitor, LJH685, suppressed BLBC cell tumourigenesis in vivo by disturbing YB-1-KLF5 axis. Our data suggest that YB-1 positively regulates KLF5 at multiple levels to promote BLBC progression. The novel RSK2-YB-1-KLF5-KRT16/Ly6D axis provides candidate diagnostic markers and therapeutic targets for BLBC.© 2021. The Author(s), under exclusive licence to ADMC Associazione Differenziamento e Morte Cellulare.

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外文
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中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 生物学
小类 | 1 区 生化与分子生物学 2 区 细胞生物学
最新[2023]版：
大类 | 1 区 生物学
小类 | 1 区 生化与分子生物学 2 区 细胞生物学
JCR分区：
出版当年[2021]版：
Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 CELL BIOLOGY
最新[2023]版：
Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 CELL BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academyof Sciences, Kunming, China [2]Kunming College of Lifesciences, University of Chinese Academy Sciences, Kunming, China
共同第一作者：
通讯作者：
通讯机构： [1]Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academyof Sciences, Kunming, China [2]Kunming College of Lifesciences, University of Chinese Academy Sciences, Kunming, China [11]KIZ-CUHK Joint Laboratory of Bioresources and MolecularResearch in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
推荐引用方式(GB/T 7714)：
Dewei Jiang,Ting Qiu,Junjiang Peng,et al.YB-1 is a positive regulator of KLF5 transcription factor in basal-like breast cancer.[J].CELL DEATH AND DIFFERENTIATION.2022,29(6):1283-1295.doi:10.1038/s41418-021-00920-x.
APA：
Dewei Jiang,Ting Qiu,Junjiang Peng,Siyuan Li,Tala...&Ceshi Chen.(2022).YB-1 is a positive regulator of KLF5 transcription factor in basal-like breast cancer..CELL DEATH AND DIFFERENTIATION,29,(6)
MLA：
Dewei Jiang,et al."YB-1 is a positive regulator of KLF5 transcription factor in basal-like breast cancer.".CELL DEATH AND DIFFERENTIATION 29..6(2022):1283-1295

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