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Plasma neurofilament light chain levels are associated with depressive and anxiety symptoms in Parkinson's disease.

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Pubmed体系：

收录情况： ◇ SCIE

作者：
Yin Weifang[1] * ; Zhu Yongyun[1] * ; Yang Baiyuan[2] * ; Wang Fang[1] ; Yin Kangfu[1] ; Zhou Chuanbin[1] ; Ren Hui[1] ; Yang Xinglong[1] ;
机构： [1]Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, 650032, People's Republic of China. [2]Department of Neurology, Seventh People's Hospital of Chengdu, Chengdu, Sichuan Province, 690041, People's Republic of China
出处：
DOI： 10.1007/s10072-022-05914-2
ISSN：

摘要：
The present study aimed to explore the association of plasma neurofilament light chain (NfL) levels with depression and anxiety in Parkinson's disease (PD). This prospective study enrolled 116 patients with PD and 38 healthy controls, and found plasma NfL levels were higher in patients with depression or anxiety than in those without these symptoms. Binary logistic regression identified NfL concentration as an independent predictor of depression and anxiety in PD. In conclusion, elevated plasma NfL may be associated with severity of depression and anxiety in PD patients and may serve as a diagnostic biomarker of PD with moderate to severe depression or anxiety.© 2022. Fondazione Società Italiana di Neurologia.

基金：
This work was supported by the National Natural Science Foundation of China (81960242), Chengdu Medical College– Chengdu Seventh People’s Hospital Joint Scientific Research Fund (2020LHJYZD-02), Yunnan Applied Basic Research Project (2019FE001-048, 202001AT070001), Yunnan Provincial Health Science and Technology Project (2018NS0102), The Applied basic Research of The Diagnosis and Treatment Center of Neurological Diseases in Yunnan Province (ZX2019-03–05), Lingnan Neurological Young and Middle-aged Doctors Clinical Research Support Project,Yunnan Province Clinical Research Center for Geriatric Diseases (202102AA310069), and Yunnan Province Clinical Research Center for Neurological Diseases (202002AA100204).
语种：
外文
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中科院(CAS)分区：
出版当年[2022]版：
大类 | 4 区 医学
小类 | 4 区 临床神经病学 4 区 神经科学
最新[2023]版：
大类 | 4 区 医学
小类 | 4 区 临床神经病学 4 区 神经科学
JCR分区：
出版当年[2021]版：
Q2 CLINICAL NEUROLOGY Q2 NEUROSCIENCES
最新[2023]版：
Q2 CLINICAL NEUROLOGY Q3 NEUROSCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, 650032, People's Republic of China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Yin Weifang,Zhu Yongyun,Yang Baiyuan,et al.Plasma neurofilament light chain levels are associated with depressive and anxiety symptoms in Parkinson's disease.[J].NEUROLOGICAL SCIENCES.2022,43(4):2839-2843.doi:10.1007/s10072-022-05914-2.
APA：
Yin Weifang,Zhu Yongyun,Yang Baiyuan,Wang Fang,Yin Kangfu...&Yang Xinglong.(2022).Plasma neurofilament light chain levels are associated with depressive and anxiety symptoms in Parkinson's disease..NEUROLOGICAL SCIENCES,43,(4)
MLA：
Yin Weifang,et al."Plasma neurofilament light chain levels are associated with depressive and anxiety symptoms in Parkinson's disease.".NEUROLOGICAL SCIENCES 43..4(2022):2839-2843

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