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Molecular characterization of echovirus 9 strains isolated from hand-foot-and-mouth disease in Kunming, Yunnan Province, China.

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机构: [1]Institute of Medical Biology, Peking Union Medical College, Chinese Academy of Medical Sciences, Kunming 650118, People’s Republic of China. [2]Yunnan Key Laboratory of Vaccine Research Development on Severe Infectious Disease, Kunming 650118, People’s Republic of China. [3]First People’s Hospital of Yunnan Province, Kunming, People’s Republic of China.
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Echovirus 9 (E9) belongs to the species Enterovirus B. So far, 12 whole genome sequences of E9 are available in GenBank. In this study, we determined the whole genomic sequences of five E9 strains isolated from the stools of patients with hand-foot-and-mouth disease in Kunming, Yunnan Province, China, in 2019. Their nucleotide and amino acid sequences shared 80.8-80.9% and 96.4-96.8% identity with the prototype Hill strain, respectively, and shared 99.3-99.9% and 99.1-99.8% mutual identity, respectively. Recombination analyses revealed that intertype recombination had occurred in the 2C and 3D regions of the five Yunnan E9 strains with coxsackieviruses B5 and B4, respectively. This study augmented the whole genome sequences of E9 in the GenBank database and extended the molecular characterization of this virus in China.© 2022. The Author(s).

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大类 | 3 区 综合性期刊
小类 | 3 区 综合性期刊
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大类 | 2 区 综合性期刊
小类 | 2 区 综合性期刊
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Q2 MULTIDISCIPLINARY SCIENCES
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Q1 MULTIDISCIPLINARY SCIENCES

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第一作者机构: [1]Institute of Medical Biology, Peking Union Medical College, Chinese Academy of Medical Sciences, Kunming 650118, People’s Republic of China. [2]Yunnan Key Laboratory of Vaccine Research Development on Severe Infectious Disease, Kunming 650118, People’s Republic of China.
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通讯机构: [1]Institute of Medical Biology, Peking Union Medical College, Chinese Academy of Medical Sciences, Kunming 650118, People’s Republic of China. [2]Yunnan Key Laboratory of Vaccine Research Development on Severe Infectious Disease, Kunming 650118, People’s Republic of China.
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