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Expression of Id3 represses exhaustion of anti-tumor CD8 T cells in liver cancer.

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机构： [1]Department of Hepatobiliary Surgery, The First People’s Hospital of Yunnan Province, Kunming, Yunnan, China [2]Research Center of Digital Medicine, The First People’s Hospital of Yunnan Province, Kunming, Yunnan, China [3]The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China [4]Linbing Biotechnology Center, Jinan, Shandong, China [5]Department of Emergency and Critical Care Medicine, Shanghai Pudong New Area People’s Hospital, Shanghai, China

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Id3, an inhibitor of DNA binding protein, plays important roles in the function and homeostasis of effector and memory T cells. Recent evidence has shown that Id3 is also implicated in CD8 T cell exhaustion. However, whether and how Id3 might regulate effector function or exhaustion of CD8 T cells, especially in the tumor setting, is still unknown. Here, we first showed that Id3 expression was impaired in tumor-infiltrating CD8 T cells as liver cancer progressed, especially in PD-1 +Tim-3 + exhausted CD8 T cells. Enforced expression of Id3 in CD8 T cells resulted in repressed development of anti-tumor CTLs exhaustion, which offered better tumor control. And partially depletion of Id3 in CD8 T cells promoted the development of exhausted CD8 T cells. Furthermore, Id3hi CD8 T cells could respond to PD-1 blockade. Collectively, Id3 exerts protective functions in CD8 T cells for liver cancer.Copyright © 2022 Elsevier Ltd. All rights reserved.

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出版当年[2022]版：

大类 | 3 区医学

小类 | 3 区免疫学 3 区生化与分子生物学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区生化与分子生物学 3 区免疫学

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出版当年[2021]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 IMMUNOLOGY

最新[2023]版：

Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 IMMUNOLOGY

影响因子： 3.2 最新[2023版] 3.6 最新五年平均 4.174 出版当年[2021版] 4.24 出版当年五年平均 4.407 出版前一年[2020版] 3.6 出版后一年[2022版]

第一作者：

第一作者机构： [1]Department of Hepatobiliary Surgery, The First People’s Hospital of Yunnan Province, Kunming, Yunnan, China [3]The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China

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通讯作者：

通讯机构： [1]Department of Hepatobiliary Surgery, The First People’s Hospital of Yunnan Province, Kunming, Yunnan, China [2]Research Center of Digital Medicine, The First People’s Hospital of Yunnan Province, Kunming, Yunnan, China [3]The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China [*1]Department of Hepatobiliary Surgery, The First People’s Hospital of Yunnan Province, Kunming, Yunnan, China.

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