个人中心| | 帮助
高级检索
当前位置： 首页 > 详情页

The S100 calcium binding protein A11 promotes liver fibrogenesis by targeting TGF-β signaling.

| 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE ◇ 统计源期刊 ◇ CSCD-C ◇ 卓越：梯队期刊

作者：
Tingting Zhu[a,b] * ; Linqiang Zhang[a] * ; Chengbin Li[c] ; Xiaoqiong Tan[a,b] ; Jing Liu[c] ; Huiqin Li[a,b] ; Qijing Fan[d] ; Zhiguo Zhang[a] ; Mingfeng Zhan[c] ; Lin Fu[c] ; Jinbo Luo[e,f] ; Jiawei Geng[e,f] ; Yingjie Wu[g,h] ; Xiaoju Zou[d] ; Bin Liang[a,c] ;
机构： [a]Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China [b]Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China [c]Center for Life Sciences, School of Life Sciences, Yunnan University, Kunming, Yunnan 650091, China [d]School of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming, Yunnan 650500, China [e]Infectious Diseases Department and Hepatic Diseases Department, The First People’s Hospital of Yunnan Province, Kunming, Yunnan 650034, China [f]Infectious Diseases Department and Hepatic Diseases Department, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan 650034, China [g]School of Laboratory Animal & Shandong Laboratory Animal Center, Science and Technology Innovation Center,Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250021, China [h]Institute for Genome Engineered Animal Models of Human Diseases, National Center of Genetically Engineered Animal Models for International Research, Liaoning Provence Key Lab of Genome Engineered Animal Models Dalian Medical University, Dalian, Liaoning 116044, China
出处：
DOI： 10.1016/j.jgg.2022.02.013
ISSN：

摘要：
Liver fibrosis is a key transformation stage and also a reversible pathological process in various types of chronic liver diseases. However, the pathogenesis of liver fibrosis still remains elusive. Here, we report that the calcium binding protein A11 (S100A11) is consistently upregulated in the integrated data from GSE liver fibrosis and tree shrew liver proteomics. S100A11 is also experimentally activated in liver fibrosis in mouse, rat, tree shrew, and human with liver fibrosis. While overexpression of S100A11 in vivo and in vitro exacerbates liver fibrosis, the inhibition of S100A11 improves liver fibrosis. Mechanistically, S100A11 activates hepatic stellate cells (HSCs) and the fibrogenesis process via the regulation of the deacetylation of Smad3 in the TGF-β signaling pathway. S100A11 physically interacts with SIRT6, a deacetylase of Smad2/3, which may competitively inhibit the interaction between SIRT6 and Smad2/3. The subsequent release and activation of Smad2/3 promote the activation of HSCs and fibrogenesis. Additionally, a significant elevation of S100A11 in serum is observed in clinical patients. Our study uncovers S100A11 as a novel profibrogenic factor in liver fibrosis, which may represent both a potential biomarker and a promising therapy target for treating liver fibrosis and fibrosis-related liver diseases.Copyright © 2022 Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Ltd. All rights reserved.

基金：
This work was supported by the National Natural Science Foundation of China (U1702288, 81700520, U1702287, 31671230, 91857113, 31860323, 32000818), the Yunnan Applied Basic Research Projects (2019FY003021, 2017FA007, 2018FB117, 202101AT070009), the Ministry of Science and Technology of the People’s Republic of China (2018YFA0800700), the Yunnan Province Innovation Team of Intestinal Microecology-Related Disease Research and Technological Transformation (202005AE160010).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 2 区 生物学
小类 | 2 区 遗传学 3 区 生化与分子生物学
最新[2023]版：
大类 | 2 区 生物学
小类 | 3 区 生化与分子生物学 3 区 遗传学
JCR分区：
出版当年[2021]版：
Q1 GENETICS & HEREDITY Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
最新[2023]版：
Q1 GENETICS & HEREDITY Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [a]Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China [b]Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China
共同第一作者：
通讯作者：
通讯机构： [a]Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China [c]Center for Life Sciences, School of Life Sciences, Yunnan University, Kunming, Yunnan 650091, China
推荐引用方式(GB/T 7714)：
Tingting Zhu,Linqiang Zhang,Chengbin Li,et al.The S100 calcium binding protein A11 promotes liver fibrogenesis by targeting TGF-β signaling.[J].JOURNAL OF GENETICS AND GENOMICS.2022,49(4):338-349.doi:10.1016/j.jgg.2022.02.013.
APA：
Tingting Zhu,Linqiang Zhang,Chengbin Li,Xiaoqiong Tan,Jing Liu...&Bin Liang.(2022).The S100 calcium binding protein A11 promotes liver fibrogenesis by targeting TGF-β signaling..JOURNAL OF GENETICS AND GENOMICS,49,(4)
MLA：
Tingting Zhu,et al."The S100 calcium binding protein A11 promotes liver fibrogenesis by targeting TGF-β signaling.".JOURNAL OF GENETICS AND GENOMICS 49..4(2022):338-349

资源点击量：82493 今日访问量：0 总访问量：681 更新日期：2025-01-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 云南省第一人民医院 技术支持：重庆聚合科技有限公司 地址：云南省昆明市西山区金碧路157号