详情页 - 云南省第一人民医院机构库

当前位置：首页 > 详情页

The impairment of the hippocampal neuro-vascular unit precedes changes in spatial cognition in naturally aged rats.

73| 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

机构： [1]Key Laboratory of Animal Models and Human Disease Mechanisms, Laboratory of Learning and Memory, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, China [2]Kunming College of Life Sciences, University of the Chinese Academy of Sciences, Kunming, China [3]Department of Neurology, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China [4]Department of Pathology and Pathophysiology, School of Basic Medical Science, Kunming Medical University, Kunming, China

出处：

DOI：

ISSN：

摘要：

Ageing is the major risk factor for the most neurodegenerative diseases, such as Alzheimer's disease (AD). Damage to neurovascular components (microvessels, glia, and neurons) occurs with ageing and is suspected to exacerbate or cause mild cognitive impairment (MCI), vascular dementia, and AD. However, whether vascular cells, glia, and neurons change synchronously or asynchronously during ageing is unclear, and the relationship between complex dynamic pathophysiological changes in the brain and cognitive ability needs to be further studied. We used male Sprague-Dawley (SD) rats of three different ages (2 months, 12 months, and 24 months) and explored changes in the neurovascular unit (cerebral vessels, microglia, astrocytes, and neurons) and spatial memory upon normal ageing by the Morris water maze (MWM) test and immunofluorescence staining. We found that the impairments of microvessels, glia, neurons, and spatial memory were age-dependent in the rat hippocampus. In middle-aged (12-month-old) rats, some neurovascular unit components have become abnormal: the density and length of microvessels, pyramidal neuron, and SST (Somatostatin) neuron number was decreased, the number of astrocytes was increased in the hippocampus. The diameter of microvessels and PV (Parvalbumin) neuron numbers were decreased, the microglial number was increased and spatial learning was deficit at 24 months of age. In conclusion, we found that the impairment of the hippocampal neuro-vascular unit precedes changes in spatial cognition in naturally aged rats.Copyright © 2022. Published by Elsevier B.V.

基金：

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2022]版：

大类 | 4 区医学

小类 | 4 区神经科学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区神经科学

JCR分区：

出版当年[2021]版：

Q3 NEUROSCIENCES

最新[2023]版：

Q3 NEUROSCIENCES

影响因子： 2.5 最新[2023版] 2.5 最新五年平均 3.197 出版当年[2021版] 2.892 出版当年五年平均 3.046 出版前一年[2020版] 2.5 出版后一年[2022版]

第一作者：

第一作者机构： [1]Key Laboratory of Animal Models and Human Disease Mechanisms, Laboratory of Learning and Memory, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, China [3]Department of Neurology, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China

共同第一作者：

通讯作者：

通讯机构： [1]Key Laboratory of Animal Models and Human Disease Mechanisms, Laboratory of Learning and Memory, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, China [2]Kunming College of Life Sciences, University of the Chinese Academy of Sciences, Kunming, China [4]Department of Pathology and Pathophysiology, School of Basic Medical Science, Kunming Medical University, Kunming, China [*1]Key Laboratory of Animal Models and Human Disease Mechanisms, Laboratory of Learning and Memory, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, China

推荐引用方式(GB/T 7714)：

APA：

MLA：