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Histone Deacetylase Inhibitors (HDACi) Promote KLF5 Ubiquitination and Degradation in Basal-like Breast Cancer.

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机构： [1]Biobank, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, 518035, China [2]Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China [3]Kunming College of Life Sciences, University of Chinese Academy Sciences, Kunming, Yunnan, China [4]Department of Pathology, Henan Provincial People’s Hospital, Zhengzhou University, Zhengzhou, Henan, 450003, China [5]Kunming Medical University, Kunming, Yunnan, 650500, China [6]Department of Dermatology, Jingmen No.1 people’s Hospital, Jingmen, Hubei, 448000, China [7]Department of the Third Breast Surgery, the Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650118, China [8]School of Life Science, University of Science & Technology of China. Hefei, Anhui, 230026, China [9]Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, 510095, China

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Basal-like breast cancer (BLBC) accounts for approximately 15% of all breast cancer cases, and patients with BLBC have a low survival rate. Our previous study demonstrated that the KLF5 transcription factor promotes BLBC cell proliferation and tumor growth. In this study, we demonstrated that the histone deacetylase inhibitors (HDACi), suberoylanilide hydroxamic acid (SAHA), and trichostatin A (TSA), increased KLF5 acetylation at lysine 369 (K369), downregulated KLF5 protein expression levels, and decreased cell viability in BLBC cell lines. HDACi target KLF5 for proteasomal degradation by promoting KLF5 protein ubiquitination. K369 acetylation of KLF5 decreases the binding between KLF5 and its deubiquitinase, BAP1. These findings revealed a novel mechanism by which HDACi suppress BLBC, and a novel crosstalk between KLF5 protein acetylation and ubiquitination.© The author(s).

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出版当年[2022]版：

大类 | 2 区生物学

小类 | 2 区生化与分子生物学

最新[2023]版：

大类 | 2 区

生物学

小类 | 2 区生化与分子生物学

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出版当年[2021]版：

Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

影响因子： 8.2 最新[2023版] 8.3 最新五年平均 10.75 出版当年[2021版] 9.445 出版当年五年平均 6.582 出版前一年[2020版] 9.2 出版后一年[2022版]

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第一作者机构： [1]Biobank, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, 518035, China

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通讯机构： [2]Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China [9]Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, 510095, China

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