Association of Preoperative Body Mass Index with Surgical Textbook Outcomes Following Hepatectomy for Hepatocellular Carcinoma: A Multicenter Study of 1206 Patients
机构:[1]Department of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University),Chongqing, China[2]Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second MilitaryMedical University (Navy Medical University), Shanghai, China[3]Division of Hepatobiliary and Pancreatic Surgery,Department of General Surgery, Cancer Center, Zhejiang Provincial People’s Hospital, People’s Hospital of HangzhouMedical College, Zhejiang, China[4]Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui MedicalUniversity, Anhui, China[5]Department of Hepatobiliary Surgery, Affiliated Hospital of Nantong University, Jiangsu,China[6]The First Department of General Surgery, The Fourth Hospital of Harbin, Heilongjiang, China[7]Department ofHepatobiliary Surgery, The First Affiliated Hospital of Harbin Medical University, Heilongjiang, China[8]Department ofGeneral Surgery, Ziyang First People’s Hospital, Sichuan, China[9]Department of Hepatobiliary Surgery, Pu’er People’sHospital, Yunnan, China[10]Department of General Surgery, Liuyang People’s Hospital, Hunan, China[11]Department ofSurgery, Wexner Medical Center, Ohio State University, Columbus, OH[12]Faculty of Medicine, The Chinese University ofHong Kong, Shatin, New Territories, Hong Kong SAR, China[13]Eastern Hepatobiliary Clinical Research Institute(EHCRI), Third Affiliated Hospital of Navy Medical University, Shanghai, China
Background Assessment of quality in the perioperative period is critical to ensure good patient care. Textbook outcomes (TO) have been proposed to combine several parameters into a single defined quality metric. The association of preoperative body mass index (BMI) with incidences of achieving or not achieving TO (non-TO) among patients undergoing hepatectomy for hepatocellular carcinoma (HCC) was characterized. Methods Patients who underwent curative-intent hepatectomy for HCC between 2015 and 2018 were identified from a multicenter database. These patients were divided into three groups based on preoperative BMI: low-BMI (<= 18.4 kg/m(2)), normal-BMI (18.5-24.9 kg/m(2)), and high-BMI (>= 25.0 kg/m(2)). The incidences of non-TO among these three groups were compared. Multivariate analyses were performed to identify whether there was any independent association between preoperative BMI and non-TO. Results Among 1206 patients, 100 (8.3%), 660 (54.7%), and 446 (37.0%) were in the low-BMI, normal-BMI, and high-BMI groups, respectively. The incidence of non-TO was 65.6% in the whole cohort. The incidence of non-TO was significantly higher among patients in the low- and high-BMI cohorts versus the normal-BMI cohort (75.0% and 74.7% versus 58.0%, both P < 0.01). After adjustment of other confounding factors on multivariate analysis, low-BMI and high-BMI were independently associated with higher incidences of non-TO compared with normal-BMI (OR: 1.98 and 2.27, both P < 0.05). Conclusions Two out of three patients did not achieve TO after hepatectomy for HCC. Both preoperative low-BMI and high-BMI were independently associated with lower odds to achieve optimal TO following HCC resection.
基金:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81874149]; Adjunct Talent Fund of Zhejiang Provincial People's Hospital [2021-YT]
第一作者机构:[1]Department of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University),Chongqing, China
通讯作者:
通讯机构:[2]Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second MilitaryMedical University (Navy Medical University), Shanghai, China[3]Division of Hepatobiliary and Pancreatic Surgery,Department of General Surgery, Cancer Center, Zhejiang Provincial People’s Hospital, People’s Hospital of HangzhouMedical College, Zhejiang, China[13]Eastern Hepatobiliary Clinical Research Institute(EHCRI), Third Affiliated Hospital of Navy Medical University, Shanghai, China
推荐引用方式(GB/T 7714):
Zhi-Peng Liu,Lan-Qing Yao,Yong-Kang Diao,et al.Association of Preoperative Body Mass Index with Surgical Textbook Outcomes Following Hepatectomy for Hepatocellular Carcinoma: A Multicenter Study of 1206 Patients[J].ANNALS OF SURGICAL ONCOLOGY.2022,29(7):4278-4286.doi:10.1245/s10434-022-11721-y.
APA:
Zhi-Peng Liu,Lan-Qing Yao,Yong-Kang Diao,Zi-Xiang Chen,Zi-Han Feng...&Tian Yang.(2022).Association of Preoperative Body Mass Index with Surgical Textbook Outcomes Following Hepatectomy for Hepatocellular Carcinoma: A Multicenter Study of 1206 Patients.ANNALS OF SURGICAL ONCOLOGY,29,(7)
MLA:
Zhi-Peng Liu,et al."Association of Preoperative Body Mass Index with Surgical Textbook Outcomes Following Hepatectomy for Hepatocellular Carcinoma: A Multicenter Study of 1206 Patients".ANNALS OF SURGICAL ONCOLOGY 29..7(2022):4278-4286