详情页 - 云南省第一人民医院机构库

当前位置：首页 > 详情页

Single-cell transcriptome analysis reveals aberrant stromal cells and heterogeneous endothelial cells in alcohol-induced osteonecrosis of the femoral head.

59| 认领 | 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

机构： [1]Department of Orthopaedic Surgery, Nanfang Hospital, Southern Medical University, 510515 Guangzhou, Guangdong, China [2]Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Southern Medical University, 510515 Guangzhou, Guangdong, China. [3]General Administration Office, ZhuJiang Hospital of Southern Medical University, 510280 Guangzhou, Guangdong, China. [4]Orthopaedic Department, The 8th medical center of Chinese PLA General Hospital, 100091 Beijing, China. [5]Department of Orthopaedic, The 920th Hospital of Joint Logistics Support Force, 650020 Kunming, Yunnan, China. [6]Department of Orthopaedic Surgery, Shunde First People Hospital, 528300 Foshan, Guangdong, China

出处：

DOI：

ISSN：

摘要：

Alcohol-induced osteonecrosis of the femoral head (ONFH) is a disabling disease with a high incidence and elusive pathogenesis. Here, we used single-cell RNA sequencing to explore the transcriptomic landscape of mid- and advanced-stage alcohol-induced ONFH. Cells derived from age-matched hip osteoarthritis and femoral neck fracture samples were used as control. Our bioinformatics analysis revealed the disorder of osteogenic-adipogenic differentiation of stromal cells in ONFH and altered regulons such as MEF2C and JUND. In addition, we reported that one of the endothelial cell clusters with ACKR1 expression exhibited strong chemotaxis and a weak angiogenic ability and expanded with disease progression. Furthermore, ligand-receptor-based cell-cell interaction analysis indicated that ACKR1+ endothelial cells might specifically communicate with stromal cells through the VISFATIN and SELE pathways, thus influencing stromal cell differentiation in ONFH. Overall, our data revealed single cell transcriptome characteristics in alcohol-induced ONFH, which may contribute to the further investigation of ONFH pathogenesis.© 2022. The Author(s).

基金：

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2022]版：

大类 | 2 区生物学

小类 | 1 区生物学

最新[2023]版：

大类 | 1 区

生物学

小类 | 1 区生物学

JCR分区：

出版当年[2021]版：

Q1 BIOLOGY

最新[2023]版：

Q1 BIOLOGY

影响因子： 5.2 最新[2023版] 5.6 最新五年平均 6.548 出版当年[2021版] 6.816 出版当年五年平均 6.268 出版前一年[2020版] 5.9 出版后一年[2022版]

第一作者：

第一作者机构： [1]Department of Orthopaedic Surgery, Nanfang Hospital, Southern Medical University, 510515 Guangzhou, Guangdong, China [2]Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Southern Medical University, 510515 Guangzhou, Guangdong, China.

共同第一作者：

通讯作者：

通讯机构： [1]Department of Orthopaedic Surgery, Nanfang Hospital, Southern Medical University, 510515 Guangzhou, Guangdong, China [2]Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Southern Medical University, 510515 Guangzhou, Guangdong, China. [6]Department of Orthopaedic Surgery, Shunde First People Hospital, 528300 Foshan, Guangdong, China

推荐引用方式(GB/T 7714)：

APA：

MLA：