个人中心| | 帮助
高级检索
当前位置： 首页 > 详情页

Neuromyelitis Optica Spectrum Disorder With Anti-Aquaporin-4 Antibody: Outcome Prediction Models.

| 认领 | 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Wang Liang[1,2] * ; Du Lei[3] * ; Li Qinying[4] * ; Li Fang[2,5] ; Wang Bei[6] ; Zhao Yuanqi[7] ; Meng Qiang[8] ; Li Wenyu[9] ; Pan Juyuan[10] ; Xia Junhui[10] ; Wu Shitao[11] ; Yang Jie[12] ; Li Heng[13] ; Ma Jianhua[3] ; ZhangBao Jingzi[1,2] ; Huang Wenjuan[1,2] ; Chang Xuechun[1,2] ; Tan Hongmei[1,2] ; Yu Jian[14] ; Zhou Lei[1,2] ; Lu Chuanzhen[1,2] ; Wang Min[14] ; Dong Qiang[1,2] ; Lu Jiahong[1,2] ; Zhao Chongbo[1,2] ; Quan Chao[1,2] ; the Pan-Yangtze River Delta Alliance for Demyelinating Disease[1] ;
机构： [1]Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2]National Center for Neurological Disorders (NCND), Shanghai, China. [3]Department of Neurology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China. [4]Department of Rehabilitation Medicine, Jing'an District Centre Hospital of Shanghai, Fudan University, Shanghai, China. [5]Department of Rehabilitation Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [6]Department of Neurology, Jing'an District Centre Hospital of Shanghai, Fudan University, Shanghai, China. [7]Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. [8]Department of Neurology, The First People's Hospital of Yunnan Province, Kunming, China. [9]Department of Neurology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China. [10]Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. [11]Department of Neurology, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, China. [12]Department of Neurology, Wuhan No.1 Hospital, Wuhan, China. [13]Department of Neurology, Central Hospital Affiliated to Shandong First Medical University, Jinan, China. [14]Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
出处：
DOI： 10.3389/fimmu.2022.873576
ISSN：

关键词： neuromyelitis optica spectrum disorder anti-aquaporin-4 antibody maintenance therapy outcome prediction model

摘要：
Recognizing the predictors of disease relapses in patients with anti-aquaporin-4 antibody (AQP4-ab)-positive neuromyelitis optica spectrum disorder (NMOSD) is essential for individualized treatment strategy. We aimed to identify the factors that predicted relapses among patients with AQP4-ab-positive NMOSD, develop outcome prediction models, and validate them in a multicenter validation cohort.Between January 2015 and December 2020, 820 patients with NMOSD were registered at Huashan Hospital. We retrospectively reviewed their medical records, and included 358 AQP4-ab-positive patients with 1135 treatment episodes. Univariate and multivariate analyses were used to explore the predictors of relapse, severe visual or motor disability during follow-up. A model predicting the 1- and 2-year relapse-free probability was developed and validated in an external validation cohort of 92 patients with 213 treatment episodes.Lower serum AQP4-ab titer (< 1:100), higher Expanded Disability Status Scale (EDSS) score at onset (≥ 2.5), and use of intravenous methylprednisolone (IVMP) at the first attack predicted an overall lower annualized relapse rate. Older age (> 48 years), optic neuritis at onset, and higher onset EDSS score (≥ 2.5) significantly increased the risk for blindness, while IVMP at the first attack and maintenance therapy reduced the risk for blindness. Myelitis at onset increased the possibility of motor disability (EDSS ≥ 6.0), severe motor disability or death (EDSS ≥ 8.0), while maintenance therapy reduced these possibilities. Anderson and Gill model identified that the risk factors predicting recurrent relapses under certain treatment status were female gender, high AQP4-ab titer (≥ 1:100), previous attack under same therapy, lower EDSS score at treatment initiation (< 2.5), and no maintenance therapy or oral prednisone lasting less than 6 months. A nomogram using the above factors showed good discrimination and calibration abilities. The concordance indexes in the primary and validation cohort were 0.66 and 0.65, respectively.This study reports the demographic, clinical and therapeutic predictors of relapse, and severe visual or motor disability in NMOSD. Early identification of patients at risk of unfavorable outcomes is of paramount importance to inform treatment decisions.Copyright © 2022 Wang, Du, Li, Li, Wang, Zhao, Meng, Li, Pan, Xia, Wu, Yang, Li, Ma, ZhangBao, Huang, Chang, Tan, Yu, Zhou, Lu, Wang, Dong, Lu, Zhao and Quan.

基金：
This research was supported by the National Natural Science Foundation of China (Grant No. 82171341, 81771296), the Shanghai Municipal Science and Technology Major Project (No. 2018SHZDZX01) and ZHANGJIANG LAB, and the National Key Research and Development Program of China (2016YFC0901504).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 2 区 医学
小类 | 2 区 免疫学
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 免疫学
JCR分区：
出版当年[2021]版：
Q1 IMMUNOLOGY
最新[2023]版：
Q1 IMMUNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2]National Center for Neurological Disorders (NCND), Shanghai, China.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2]National Center for Neurological Disorders (NCND), Shanghai, China.
推荐引用方式(GB/T 7714)：
Wang Liang,Du Lei,Li Qinying,et al.Neuromyelitis Optica Spectrum Disorder With Anti-Aquaporin-4 Antibody: Outcome Prediction Models.[J].FRONTIERS IN IMMUNOLOGY.2022,13:doi:10.3389/fimmu.2022.873576.
APA：
Wang Liang,Du Lei,Li Qinying,Li Fang,Wang Bei...&the Pan-Yangtze River Delta Alliance for Demyelinating Disease.(2022).Neuromyelitis Optica Spectrum Disorder With Anti-Aquaporin-4 Antibody: Outcome Prediction Models..FRONTIERS IN IMMUNOLOGY,13,
MLA：
Wang Liang,et al."Neuromyelitis Optica Spectrum Disorder With Anti-Aquaporin-4 Antibody: Outcome Prediction Models.".FRONTIERS IN IMMUNOLOGY 13.(2022)

相关文献

[1]Deep learning-based relapse prediction of neuromyelitis optica spectrum disorder with anti-aquaporin-4 antibody [2]Neuromyelitis optica spectrum disorder in three generations of a Chinese family [3]Construction of diagnostic prediction model for Wilson's disease [4]Ixazomib Based Maintenance Therapy for the Patients with Newly Diagnosed Multiple Myeloma in Real-World Practice [5]胰腺癌细胞焦亡相关基因风险预测模型的构建 [6]Deep-Learning Model for Influenza Prediction From Multisource Heterogeneous Data in a Megacity: Model Development and Evaluation [7]Influenza Epidemic Trend Surveillance and Prediction Based on Search Engine Data: Deep Learning Model Study [8]Interpretable Machine Learning Model for Early Prediction of Mortality in ICU Patients with Rhabdomyolysis. [9]Development and validation of a model for the early prediction of the RRT requirement in patients with rhabdomyolysis. [10]基于Borderline-SMOTE和PFS构建非小细胞肺癌生存预测模型

资源点击量：82490 今日访问量：0 总访问量：681 更新日期：2025-01-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 云南省第一人民医院 技术支持：重庆聚合科技有限公司 地址：云南省昆明市西山区金碧路157号