Posterior reversible encephalopathy syndrome is an uncommon syndrome in exertional rhabdomyolysis. We herein report a case of rhabdomyolysis and acute kidney injury after intense exercise. The patient also had generalized hypertension, headache, and painless complete loss of vision in both eyes, which was consistent with the symptoms of posterior reversible encephalopathy syndrome detected by magnetic resonance imaging of the brain. The patient fully recovered through active fluid replacement, diuresis, blood pressure control, alkalization of urine and blood purification, and supportive measures. This case report describes an infrequent neurological complication of exertional rhabdomyolysis. Understanding the range of complications is critical for improving patient outcomes.