In this study, the protective effects of hot water (QW) and aqueous-ethanol extracts (QA) from Que Zui tea on non-alcoholic fatty liver disease (NAFLD) were investigated. Quantitative and qualitative analysis revealed that QW and QA were rich in polyphenols, especially 6'-O-caffeoylarbutin. Both QW and QA significantly reduced body weight and liver index, increased serum levels of high density lipoprotein cholesterol (HDL-C), and decreased the levels of total cholesterol (TC), triglyceride (TG), nonesterified free fatty acids (NEFA) and low density lipoprotein cholesterol (LDL-C) in NAFLD rats induced high fat diet. Furthermore, the contents of TC, TG, NEFA, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the liver tissues were inhibited after QW and QA administration. Histopathological examination showed that QW and QA significantly reduced liver lipid accumulation of NAFLD rats. In addition, QW and QA could enhance increase the activity of antioxidant (glutathione, superoxide dismutase and catalase) in the liver by regulation Nrf2 signaling pathway, thereby alleviating liver damage caused by lipid peroxidation. QW and QA activated AMPK/PPAR-alpha signaling pathway by increasing the expression of adiponectin and its receptor AdipoR2, thereby reducing fat production and enhancing fatty acid beta oxidation. These data suggested that QW and QA had the potential to in the prevention and treatment of NAFLD.
基金：
Yunnan Major Natural Science [2019ZF010]; Yunnan Ten-thousand Talents Program
第一作者机构：[1]Kunming Univ Sci & Technol, Fac Food Sci & Engn, Kunming 650500, Peoples R China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Zhang Jin-Ke,Zhou Xiu-Li,Wang Xiao-Qian,et al.Que Zui tea ameliorates hepatic lipid accumulation and oxidative stress in high fat diet induced nonalcoholic fatty liver disease[J].FOOD RESEARCH INTERNATIONAL.2022,156:doi:10.1016/j.foodres.2022.111196.
APA：
Zhang, Jin-Ke,Zhou, Xiu-Li,Wang, Xiao-Qian,Zhang, Jia-Xiong,Yang, Mei-Lian...&Cheng, Gui-Guang.(2022).Que Zui tea ameliorates hepatic lipid accumulation and oxidative stress in high fat diet induced nonalcoholic fatty liver disease.FOOD RESEARCH INTERNATIONAL,156,
MLA：
Zhang, Jin-Ke,et al."Que Zui tea ameliorates hepatic lipid accumulation and oxidative stress in high fat diet induced nonalcoholic fatty liver disease".FOOD RESEARCH INTERNATIONAL 156.(2022)
农林科学