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Selective High Frequency Oscillatory Ventilation (HFOV) for Neonates

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研究单位： [1]Children's Hospital of Chongqing Medical University Chongqing, Chongqing, China, 400042 [2]Jiulongpo No.1 People's Hospital [3]Chongqing Maternal and Child Health Hospital [4]The First Affiliated Hospital of Anhui Medical University [5]Children's Hospital of The Capital Institute of Pediatrics [6]Peking University Third Hospital [7]First Hospital of Tsinghua University [8]Women and Children's Hospital, Branch of Chongqing Sanxia Central Hospital [9]First Affiliated Hospital of Chongqing Medical University [10]Quanzhou Children's Hospital [11]Xiamen Maternity & Child Care Hospital [12]Zhujiang Hospital [13]Nanfang Hospital of Southern Medical University [14]Guangdong Academy of Medical Science and General Hospital [15]Guangdong Women and Children Hospital [16]Women and Children's Health Hospital of Yulin [17]Women and Children Health Care Hospitalof GuangXi Zhuang Autonomous [18]Second Affiliated Hospital of Guangzhou Medical University [19]Guiyang Maternal and Child Health Care Hospital [20]Zunyi First People's Hospital [21]Second Hospital of Lanzhou University [22]Gansu Provincial Maternity and Child-Care Hospital [23]LanZhou University [24]First Affiliated Hospital of Harbin Medical University [25]First Affiliated Hospital of Xinjiang Medical University [26]Zhengzhou Children's Hospital, China [27]Third Affiliated Hospital of Zhengzhou University [28]the Maternal and Child Health Hospital of Hainan Province [29]Bethune International Peace Hospital [30]Wuhan Union Hospital, China [31]Children's Hospital of Nanjing Medical University [32]The First Hospital of Jilin University [33]Children's Hospital of Fudan University [34]Maternal and Children's Healthcare Hospital of Taian [35]The Second Hospital of Shandong University [36]Shanxi Provincial Maternity and Children's Hospital [37]Chengdu Women and Children's Center Hospital [38]The Affiliated Hospital Of Southwest Medical University [39]Affiliated Hospital of Southwest Medical University [40]Shenzhen People's Hospital, The Second Medical College of Jinan University [41]Tianjin Central Hospital of Gynecology Obstetrics [42]People's Hospital of Xinjiang Uygur Autonomous Region [43]Kunming Children's Hospital [44]The First People's Hospital of Yunnan [45]First Affiliated Hospital of Kunming Medical University [46]Yan'an Affiliated Hospital of Kunming Medical University [47]Women and Children's Health Hospital of Qujing [48]The People's Hospital of Dehong Autonomous Prefecture [49]Yinchuan No 1 people's Hospital Affiliated of Ningxia Medical University [50]The Children's Hospital of Zhejiang University School of Medicine [51]Women's Hospital School Of Medicine Zhejiang University [52]Beijing 302 Hospital [53]Hunan Children's Hospital [54]Women and Children Hospital of Qinghai Province [55]Jiangxi Province Children's Hospital [56]Inner Mongolia People's Hospital [57]Mianyang Central Hospital [58]People's Liberation Army No.202 Hospital [59]Ningbo Women & Children's Hospital [60]Shanghai Children's Medical Center [61]First Affiliated Hospital of Guangxi Medical University [62]Nanjing Medical University [63]Xianyang Children's Hospital [64]Qinhuangdao Maternal and Child Health Care Hospital [65]Xuzhou Children Hospital

研究目的：

Neonatal respiratory distress syndrome (RDS) remains a major respiratory disorder for the increasing preterm population, and its incidence has been confirmed to be increased gradually with decreased gestational age. Previous studies demonstrated incidences of 90% at 24 weeks', 80% at 28 weeks', 57% at 30-31 weeks', and 25% at 35-36 weeks' gestational age(GA). However, these figures were mainly performed in the pre-neonatal acute respiratory distress syndrome (ARDS) era, in which ARDS was usually considered as RDS, and surfactant was therefore used repeatedly. In fact, no studies have indicated beneficial effects of surfactant for adult and pediatric ARDS, and therefore, its exact action for neonatal ARDS was needed to be further elucidated. In 2017, the international ARDS collaborative group provided the first consensus definition for neonatal ARDS, and the exact incidence of neonatal ARDS and mortality were unknown.