研究单位:[1]Children's Hospital of Chongqing Medical University[2]Jiulongpo No.1 People's Hospital[3]Jiangxi Maternal and Child Health Hospital[4]Guiyang Maternity and Child Health Care Hospital[5]The Second Hospital of Shandong University[6]Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region[7]Hunan Provincial Maternal and Child Health Care Hospital[8]Zhangzhou Affiliated Hospital of Fujian Medical University[9]Women and Children's Health Hospital of Yulin[10]Chongqing Three Gorges Central Hospital[11]Gansu Provincial Maternal and Child Health Care Hospital[12]The First People's Hospital of Yunnan[13]Chengdu Women's and Children's Central Hospital[14]Maternal and Children's Healthcare Hospital of Taian[15]People's Hospital of Xinjiang Uygur Autonomous Region[16]Quanzhou Children's Hospital[17]Chongqing West Hospital[18]Chongqing Medical Center for Women and Children[19]Xiamen Maternity & Child Care Hospital[20]Qujing Maternal and Child Health Hospital[21]Liuzhou Maternity and Child Healthcare Hospital[22]International Peace Maternity and Child Health Hospital[23]Hunan Provincial Maternal and Child Health Care Hospital,Changsha,Hunan,China[24]The Second Hospital of Shandong University,Jinan,Shandong,China[25]Qujing Maternity and cChild Healthcare Hospital,Qujing,Yunnan,China
This will be a prospective, multi-center, two-arms,parallel, randomized, controlled trial with a superiority design,conducted in China. The investigators conduct this multi-centre, randomized, controlled trial to test the hypothesis that NHFOV is more effective than nCPAP in the treatment of respiratory distress syndrome (RDS) in infants with a gestational age of less than 28 weeks when used as a primary noninvasive ventilation (NIV) mode.