研究单位：[1]BeiGene[2]Amicis Research Center,Northridge,California,United States,91324[3]Stanford University,Palo Alto,California,United States,94304[4]Northwestern University Feinberg School of Medicine,Chicago,Illinois,United States,60611[5]Northshore University Healthsystem,Evanston,Illinois,United States,60201[6]Intermed Consultants,Edina,Minnesota,United States,55435[7]Kidney Specialist of Southern Nevada (Ksosn),Las Vegas,Nevada,United States,89106[8]Donald and Barbara Zucker School of Medicine At Northwell Health,Great Neck,New York,United States,11021[9]University of Cincinnati Cancer Center,Cincinnati,Ohio,United States,45267[10]Carolina Nephrology,Spartanburg,South Carolina,United States,29306[11]Prolato Clinical Research Center,Houston,Texas,United States,77054[12]Medical College of Wisconsin,Milwaukee,Wisconsin,United States,53226[13]Investigacion Clinica Aplicada,Buenos Aires,Argentina,1865[14]Centro de Investigaciones Madicas Mar Del Plata,Mar del Plata,Argentina,7600[15]Cer San Juan Centro Polivalente de Asistencia E Investigacian Clanica,San Juan,Argentina,5400[16]Centro de Investigaciones Medicas Tucuman,San Miguel de Tucuman,Argentina,4000[17]Clipem Clinica E Pesquisa Em Endocrinologia de Maringa,Maringa,Brazil,87000-000[18]Hospital Das Clnicas Da Universidade Federal de Pernambuco,Recife,Brazil,50000-000[19]Hospital Das Clinicas Da Faculdade de Medicina de Ribeirao Preto Usp,Ribeirao Preto,Brazil,14051140[20]Hospital Alemao Oswaldo Cruz,Sao Paulo,Brazil,04829-310[21]Chum Centre de Recherche,Montreal,Canada,H2X 3E4[22]Cisss de La Monteregie Centre,Quebec,Canada,G1S 1L7[23]Ott Healthcare, Inc,Scarborough,Canada,M1H 3G4[24]University of British Columbia,Vancouver,Canada,V6K 2P1[25]Beijing An Zhen Hospital of the Capital University of Medical Sciences,Beijing,Beijing,China,100029[26]Peking University First Hospital,Beijing,Beijing,China,100034[27]Peking University Peoples Hospital,Beijing,Beijing,China,100044[28]The First Affiliated Hospital of Fujian Medical University,Fuzhou,Fujian,China,350005[29]Guangdong Provincial Peoples Hospital,Guangzhou,Guangdong,China,510080[30]The First Affiliated Hospital, Sun Yat Sen University,Guangzhou,Guangdong,China,510080[31]Peking University Shenzhen Hospital,Shenzhen,Guangdong,China,518036[32]The First Affiliated Hospital of Guangxi Medical University,Nanning,Guangxi,China,530021[33]Guizhou Provincial Peoples Hospital,Guiyang,Guizhou,China,550002[34]The First Hospital of Hebei Medical University,Shijiazhuang,Hebei,China,50000[35]Nanyang Central Hospital,Nanyang,Henan,China,473000[36]The First Affiliated Hospital of Xinxiang Medical University,Xinxiang,Henan,China,453100[37]The First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan,China,450052[38]Renmin Hospital of Wuhan University,Wuhan,Hubei,China,430060[39]Zhongda Hospital Southeast University,Nanjing,Jiangsu,China,210009[40]Jiangsu Province Hospital,Nanjing,Jiangsu,China,210029[41]Wuxi Peoples Hospital,Wuxi,Jiangsu,China,214023[42]Affiliated Hospital of Jiangsu University,Zhenjiang,Jiangsu,China,212001[43]First Affiliated Hospital of Dalian Medical University,Dalian,Liaoning,China,116011[44]Shengjing Hospital of China Medical University,Shenyang,Liaoning,China,110004[45]General Hospital of Ningxia Medical University,Yinchuan,Ningxia,China,750004[46]Shandong Provincial Hospital,Jinan,Shandong,China,250021[47]The Affiliated Hospital of Qingdao University Branch South,Qingdao,Shandong,China,266000[48]Rui Jin Hospital Shanghai Jiao Tong University School of Medicine,Shanghai,Shanghai,China,200025[49]Shanghai General Hospital,Shanghai,Shanghai,China,200080[50]Shanxi Provincial Peoples Hospital,Taiyuan,Shanxi,China,030012[51]Sichuan Academy of Medical Sciences and Sichuan Provincial Peoples Hospital,Chengdu,Sichuan,China,610071[52]Tianjin Union Medical Center (Nankai University Affiliated Hospital),Tianjin,Tianjin,China,300121[53]The First Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang,China,830054[54]The First Peoples Hospital of Yunnan Province,Kunming,Yunnan,China,650034[55]The First Affiliated Hospital, Zhejiang University School of Medicine,Hangzhou,Zhejiang,China,310003[56]Zhejiang Provincial Peoples Hospital,Hangzhou,Zhejiang,China,310014[57]Fakultni Nemocnice Olomouc,Olomouc,Czechia,77900[58]Vseobecna Fakultni Nemocnice V Praze,Praha,Czechia,10000[59]Azienda Ospedaliera Universitaria Policlinico Santorsola Malpighi,Bologna,Italy,40138[60]Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia,Brescia,Italy,25123[61]Istscientifico Di Pavia, Fondazione Smaugeri, Irccs, Clinica Del Lavoro E Della Riabilitazione,Pavia,Italy,27100[62]Centenario Hospital Miguel Hidalgo,Aguascalientes,Mexico,2008[63]Hospital Angeles Chihuahua,Chihuahua,Mexico,31104[64]Morales Vargas Centro de Investigacion Sc,Leon,Mexico,36090[65]IECSI,Monterrey,Mexico,64310[66]Spzoz Centralny Szpital Kliniczny Um W Lodzi,Lodz,Poland,92-213[67]Wojewodzki Specjalistyczny Szpital W Olsztynie,Olsztyn,Poland,10-561[68]Uniwersytecki Szpital Kliniczny Im Jana Mikulicza Radeckiego We Wroclawiu,Wroclaw,Poland,50-556[69]Hospital Universitario Vall Dhebron,Barcelona,Spain,08035[70]Fundacion Puigvert,Barcelona,Spain,8025[71]Hospital Clinico San Carlos,Madrid,Spain,28040[72]Hospital Universitario Virgen Del Rocio,Sevilla,Spain,41013[73]Erciyes University Medical Faculty,Erciyes,Turkey,38030[74]Kocaeli University Research and Application Hospital Department of Nephrology,Kocaeli,Turkey,41380[75]Kahramanmaras Sutcu Imam University,Onikiubat,Turkey,46050[76]St Heliers Hospital,Sutton,Carlshalton,United Kingdom,SM5 1AA[77]Aberdeen Royal Infirmary,Aberdeen,United Kingdom,AB25 2ZN[78]Royal Derby Hospital,Derby,United Kingdom,DE22 3NE[79]Aintree University Hospital,Liverpool,United Kingdom,L9 7AL[80]Hammersmith Hospital,London,United Kingdom,W12 0HS[81]Manchester Royal Infirmary,Manchester,United Kingdom,M13 9WL
研究目的：
The primary objectives of this study are: In Part 1 to evaluate the efficacy of zanubrutinib as measured by proteinuria reduction, and in Part 2 to evaluate the efficacy of zanubrutinib compared with tacrolimus as measured by complete remission rate, in participants with primary membranous nephropathy who are on optimal supportive care.
