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A Study of Orforglipron (LY3502970) in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities

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研究单位: [1]Eli Lilly and Company [2],Spain,15006 [3],Spain,15405 [4],Spain,08916 [5],Spain,08022 [6],Spain,08035 [7]The Institute for Liver Health dba Arizona Clinical Trials,Mesa,Arizona,United States,85210 [8]Clinical Research Institute of Arizona (CRI) - Sun City West,Sun City West,Arizona,United States,85375 [9]John Muir Physician Network Research Center,Concord,California,United States,94520 [10]AMCR Institute,Escondido,California,United States,92025 [11]NorCal Medical Research, Inc,Greenbrae,California,United States,94904 [12]Velocity Clinical Research, Huntington Park,Huntington Park,California,United States,90255 [13]Velocity Clinical Research, Westlake,Los Angeles,California,United States,90057 [14]Catalina Research Institute, LLC,Montclair,California,United States,91763 [15]Norcal Endocrinology & Internal Medicine,San Ramon,California,United States,94583 [16]University Clinical Investigators, Inc.,Tustin,California,United States,92780 [17]University of Colorado Anschutz Medical Campus,Aurora,Colorado,United States,80045 [18]New Age Medical Research Corporation,Miami,Florida,United States,33186 [19]Renstar Medical Research,Ocala,Florida,United States,34470 [20]Henan Cancer Hospital ( Site 3309),Zhengzhou,Henan,China,450008 [21]Jedidiah Clinical Research - Tampa - Bay Plaza,Tampa,Florida,United States,33619 [22]Clinical Site Partners LLC, dba CSP Orlando,Winter Park,Florida,United States,32789 [23]Physicians Research Associates,Lawrenceville,Georgia,United States,30046 [24]East Coast Institute for Research, LLC,Macon,Georgia,United States,31210 [25]Rophe Adult and Pediatric Medicine/SKYCRNG,Union City,Georgia,United States,30291 [26]East-West Medical Research Institute,Honolulu,Hawaii,United States,96814 [27]Elite Clinical Trials,Blackfoot,Idaho,United States,83221 [28]Cotton O'Neil Clinical Research Center,Topeka,Kansas,United States,66606 [29]Cotton O'Neil Clinical Research Center,Topeka,Kansas,United States,66606 [30]Pennington Biomedical Research Center,Baton Rouge,Louisiana,United States,70808 [31]Care Access - Lake Charles,Lake Charles,Louisiana,United States,70601 [32]MedStar Health Research Institute (MedStar Physician Based Research Network),Hyattsville,Maryland,United States,20782 [33]Endocrine and Metabolic Consultants,Rockville,Maryland,United States,20852 [34]Arcturus Healthcare , PLC, Troy Internal Medicine Research Division,Troy,Michigan,United States,48098 [35]SKY Integrative Medical Center/SKYCRNG,Ridgeland,Mississippi,United States,39157 [36]Las Vegas Medical Research,Las Vegas,Nevada,United States,89113 [37]Long Island Cardiovascular Consultants,Lake Success,New York,United States,11042 [38]Weill Cornell Medical College,New York,New York,United States,10021 [39]Alliance for Multispecialty Research, LLC,Norman,Oklahoma,United States,73069 [40]Texas Diabetes & Endocrinology, P.A.,Austin,Texas,United States,78731 [41]Thyroid, Endocrinology, and Diabetes,Dallas,Texas,United States,75208 [42]Velocity Clinical Research, Dallas,Dallas,Texas,United States,75230 [43]Cedar Health Research,Dallas,Texas,United States,75251 [44]Juno Research,Houston,Texas,United States,77054 [45]Consano Clinical Research, LLC,Shavano Park,Texas,United States,78231 [46]Soma Clinical Trials,Wylie,Texas,United States,75098 [47]Physicians' Research Options,Draper,Utah,United States,84020 [48]Health Research of Hampton Roads, Inc.,Newport News,Virginia,United States,23606 [49]Eastside Research Associates,Redmond,Washington,United States,98052 [50]Centro de Pesquisas em Diabetes e Doenças Endócrino-Metabólicas,Fortaleza,Ceará,Brazil,60160-140 [51]Hospital Brasilia,Brasilia,Distrito Federal,Brazil,71681-603 [52]CEDOES,Vitória,Espírito Santo,Brazil,29055450 [53]Hospital São Domingos,Bequimao,Maranhão,Brazil,65060-645 [54]Cline Research Center,Curitiba,Paraná,Brazil,80030-480 [55]Quanta Diagnóstico e Terapia,Curitiba,Paraná,Brazil,80045170 [56]Núcleo de Pesquisa Clínica do Rio Grande do Sul,Porto Alegre,Rio Grande Do Sul,Brazil,90430-001 [57]Centro de Pesquisa Sao Lucas,Campinas,São Paulo,Brazil,13060-803 [58]CECIP - Centro de Estudos do Interior Paulista,Jau,São Paulo,Brazil,17201130 [59]Centro Multidisciplinar de Estudos Clinicos,Sao Bernardo do Campo,São Paulo,Brazil,09715-090 [60]Integral Pesquisa e Ensino,Votuporanga,São Paulo,Brazil,15501-405 [61]Hospital São Lucas Copacabana,Rio de Janeiro,Brazil,22061-080 [62]CPQuali Pesquisa Clínica,São Paulo,Brazil,01228-000 [63]CEPIC - Centro Paulista de Investigação Clínica,São Paulo,Brazil,04266-010 [64]Hospital das Clinicas FMUSP,São Paulo,Brazil,05403-000 [65]Chinese PLA General Hospital,Beijing,Beijing,China,100853 [66]Chongqing General Hospital,Chongqing,Chongqing,China,400014 [67]Hainan General Hospital,Haikou,Hainan,China,570311 [68]The First Affiliated Hospital of Henan University of Science &Technology,Luoyang,Henan,China,471003 [69]The Second Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan,China,450014 [70]Nanjing First Hospital,Nanjing,Jiangsu,China,210006 [71]The Second Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu,China,210011 [72]The First Affiliated Hospital of Soochow University,Suzhou,Jiangsu,China,215006 [73]Affiliated Hospital of Jiangsu University,Zhenjiang,Jiangsu,China,212000 [74]The Fourth Hospital of Harbin Medical University,Harbin,Nangang District,China,150001 [75]Jinan Central Hospital,Jinan,Shandong,China,250013 [76]Tianjin Medical University General Hospital,Tianjin,Tianjin,China,300052 [77]Tianjin Medical University Zhu Xianyi Memorial Hospital,Tianjin,Tianjin,China [78]The First People's Hospital of Yunnan Province,Kunming,Yunnan,China,650034 [79]Zhejiang Hospital,Hangzhou,Zhejiang,China,310013 [80]Ningbo First Hospital,Ningbo,Zhejiang,China,315010 [81]Endolife Speciality Hospitals,Guntur,Andhra Pradesh,India,522001 [82]Victoria Hospital, Bangalore Medical College And Research Institute,Bangalore,Karnataka,India,560002 [83]Mysore Medical College,Mysore,Karnataka,India,570001 [84]Grant Govt. Medical College & Sir J. J. Group of Hospitals,Mumbai,Maharashtra,India,400008 [85]Government Medical College And Hospital - Nagpur,Nagpur,Maharashtra,India,440009 [86]All India Institute of Medical Sciences (AIIMS) - Nagpur,Nagpur,Maharashtra,India,441108 [87]Deenanath Mangeshkar Hospital & Research Centre,Pune,Maharashtra,India,411004 [88]Sahyadri Super Speciality Hospital,Pune,Maharashtra,India,411004 [89]Lifepoint Multispeciality Hospital,Pune,Maharashtra,India,411057 [90]All India Institute of Medical Sciences,Bhubaneswar,Odisha,India,751019 [91]Oishi Clinic,Kasuya,Fukuoka,Japan,811-2310 [92]Mazda Hospital,Aki-gun,Hiroshima,Japan,735-0017 [93]NTT Nishinihon Takamatsu Clinic,Takamatsu,Kagawa,Japan,760-0076 [94]Iwamoto Internal Medicine Clinic,Zentsujichó,Kagawa,Japan,765-0071 [95]Yokkaichi Diabetes Clinic,Yokkaichi,Mie,Japan,510-0829 [96]Medical Corporation Heishinkai OCROM Clinic,Suita-shi,Osaka,Japan,565-0853 [97]Sugiura Internal Medicine Clinic,Soka,Saitama,Japan,340-0034 [98]Adachi Kyosai Hospital,Adachi-ku,Tokyo,Japan,120-0022 [99]Tokyo-Eki Center-building Clinic,Chuo-ku,Tokyo,Japan,103-0027 [100]Medical Corporation Chiseikai Tokyo Center Clinic,Chuo-ku,Tokyo,Japan,103-0028 [101]Fukuwa Clinic,Chuo-ku,Tokyo,Japan,104-0031 [102]Yutenji Medical Clinic,Meguro-ku,Tokyo,Japan,153-0053 [103]Kanno Naika,Mitaka,Tokyo,Japan,181-0013 [104]Heishinkai Medical Group ToCROM Clinic,Shinjuku-ku,Tokyo,Japan,160-0008 [105]Boocs Clinic Fukuoka,Fukuoka,Japan,812-0025 [106]AMC Nishiumeda Clinic,Osaka,Japan,530-0001 [107]Shimokitazawa Tomo Clinic,Tokyo,Japan,155-0031 [108]Yokohama Minoru Clinic,Yokohama,Japan,232-0064 [109]Gachon University Gil Medical Center,Namdong,Incheon-gw,Korea, Republic of,21565 [110]Hallym University Sacred Heart Hospital,Anyang-si,Kyǒnggi-do,Korea, Republic of,14068 [111]Ajou University Hospital,Suwon,Kyǒnggi-do,Korea, Republic of,16499 [112]Pusan National University Yangsan Hospital,Busan,Kyǒngsangnam-do,Korea, Republic of,50612 [113]Seoul National University Hospital,Seoul,Seoul-teuk,Korea, Republic of [114]Konyang University Hospital,Seogu,Taejǒn-Kwangyǒkshi,Korea, Republic of,35365 [115]Dorado Medical Complex,Dorado,Puerto Rico,00646 [116]GCM Medical Group, PSC - Hato Rey Site,San Juan,Puerto Rico,917 [117]Nemocnica s poliklinikou Lucenec,Lucenec,Banskobystrický Kraj,Slovakia,984 01 [118]Metabol KLINIK,Bratislava,Bratislavský Kraj,Slovakia,811 08 [119]Human Care s.r.o.,Kosice,Košický Kraj,Slovakia,04001 [120]Areteus s.r.o.,Trebisov,Košický Kraj,Slovakia,075 01 [121]DIAB sro,Roznava,Košický Kr,Slovakia,048 01 [122]MEDI-DIA s.r.o.,Sabinov,Prešovský Kraj,Slovakia,083 01 [123]DIA-MED CENTRUM s.r.o.,Puchov,Trenčiansky Kraj,Slovakia,020 01 [124]MediTask,Bratislava,Slovakia,831 03 [125]Centro Periférico de Especialidades Bola Azul,Almeria,Almería,Spain,04009 [126]Hospital Quiron Infanta Luisa,Sevilla,Andalucía,Spain,41010 [127]Hospital Clínico Universitario de Valladolid,Valladolid,Castilla Y León,Spain,47010 [128]Hospital Virgen del Camino,Sanlúcar de Barrameda,Cádiz,Spain,11540 [129]Hospital Virgen de las Montañas,Villamartin,Cádiz,Spain,11650 [130]Hospital General Universitario de Valencia,Valencia,Valenciana, Comunitat,Spain,46014 [131]Hospital Universitari I Politecnic La Fe,València,Spain,46026 [132]Chiayi Christian Hospital,Chiayi City,Chiayi,Taiwan,600 [133]Changhua Christian Hospital,Changhua,Taiwan,50006 [134]Kaohsiung Medical University Chung-Ho Memorial Hospital,Kaohsiung,Taiwan,807 [135]Chang Gung Memorial Hospital at Kaohsiung,Kaohsiung,Taiwan,83301 [136]National Cheng Kung University Hospital,Tainan,Taiwan,704

研究目的:
This study will investigate the efficacy and safety of once daily oral orforglipron in adult participants with obesity or overweight with weight-related comorbidities.

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