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A Study of Orforglipron in Adult Participants With Obesity or Overweight and Type 2 Diabetes

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研究单位: [1]Eli Lilly and Company [2],Korea, Republic of,02841 [3],Korea, Republic of,134-090 [4],Korea, Republic of,6591 [5]Cahaba Research - Pelham,Pelham,Alabama,United States,35124 [6]Novak Clinical Research - Tucson - North La Cholla Boulevard,Tucson,Arizona,United States,85741 [7]Yuma Clinical Trials,Yuma,Arizona,United States,85364 [8]AMCR Institute,Escondido,California,United States,92025 [9]Velocity Clinical Research, Huntington Park,Huntington Park,California,United States,90255 [10]Velocity Clinical Research, Westlake,Los Angeles,California,United States,90057 [11]Catalina Research Institute, LLC,Montclair,California,United States,91763 [12]University Clinical Investigators, Inc.,Tustin,California,United States,92780 [13]Encore Medical Research,Hollywood,Florida,United States,33021 [14]East Coast Institute for Research, LLC,Jacksonville,Florida,United States,32216 [15]South Florida Clinical Research Institute,Margate,Florida,United States,33063 [16]Suncoast Clinical Research, Inc.,New Port Richey,Florida,United States,34652 [17]Balanced Life Health Care Solutions/SKYCRNG,Lawrenceville,Georgia,United States,30046 [18]Endocrine Research Solutions, Inc.,Roswell,Georgia,United States,30076 [19]North Georgia Clinical Research,Woodstock,Georgia,United States,30189 [20]Pacific Diabetes & Endocrine Center,Honolulu,Hawaii,United States,96813 [21]Solaris Clinical Research,Meridian,Idaho,United States,83646 [22]Iowa Diabetes and Endocrinology Research Center,West Des Moines,Iowa,United States,50265 [23]MedStar Good Samaritan Hospital,Baltimore,Maryland,United States,21239 [24]Arcturus Healthcare , PLC, Troy Internal Medicine Research Division,Troy,Michigan,United States,48098 [25]StudyMetrix Research,Saint Peters,Missouri,United States,63303 [26]Las Vegas Medical Research,Las Vegas,Nevada,United States,89113 [27]IMA Clinical Research,Albuquerque,New Mexico,United States,87109 [28]Albany Medical College, Division of Community Endocrinology,Albany,New York,United States,12203 [29]Albany Stratton VA Medical Center,Albany,New York,United States,12208 [30]NYC Research INC,Long Island City,New York,United States,11106 [31]Accellacare - Raleigh,Raleigh,North Carolina,United States,27609 [32]Summit Headlands,Portland,Oregon,United States,97210 [33]Alliance for Multispecialty Research, LLC,Knoxville,Tennessee,United States,37909 [34]Velocity Clinical Research, Dallas,Dallas,Texas,United States,75230 [35]Soma Clinical Trials,Denison,Texas,United States,75020 [36]Biopharma Informatic, LLC,Houston,Texas,United States,77043 [37]Epic Medical Research,Red Oak,Texas,United States,75154 [38]Diabetes and Glandular Disease Center,San Antonio,Texas,United States,78229 [39]VIP Trials,San Antonio,Texas,United States,78230 [40]Charlottesville Medical Research,Charlottesville,Virginia,United States,22911 [41]Universal Research Group,Tacoma,Washington,United States,98405 [42]CEMEDIAB,C.a.b.a.,Ciudad Aut,Argentina,C1205AAO [43]Mautalen Salud e Investigación,Buenos Aires,Ciudad Autónoma De Buenos Aire,Argentina,C1128AAF [44]Instituto Centenario,Caba,Ciudad Autónoma De Buenos Aire,Argentina,1204 [45]Instituto Médico Fundación Grupo Colaborativo Rosario Investigación y Prevención Medica,Rosario,Santa Fe,Argentina,2000 [46]Instituto de Investigaciones Clinicas Rosario,Rosario,Santa Fe,Argentina,S2000CVD [47]Sanatorio San Martin,Venado Tuerto,Santa Fe,Argentina,2600 [48]Centro de Investigaciones Médicas Tucuman,SAN M. DE Tucuman,Tucumán,Argentina,T4000AXL [49]CONEXA Investigacion Clinica S.A.,Buenos Aires,Argentina,1012 [50]Centro Diabetológico Dr. Waitman,Córdoba,Argentina,5000 [51]Clínica Universitaria Reina Fabiola,Córdoba,Argentina,X50004FHP [52]Centro de Diagnóstico y Rehabilitación (CEDIR),Santa Fe,Argentina,3000 [53]Emeritus Research,Botany,New South Wales,Australia,2019 [54]The AIM Centre / Hunter Diabetes Centre,Merewether,New South Wales,Australia,2291 [55]Royal Brisbane and Women's Hospital,Brisbane,Queensland,Australia,4029 [56]Core Research Group,Brisbane,Queensland,Australia,4064 [57]Logan Hospital,Meadowbrook,Queensland,Australia,4131 [58]Southern Adelaide Diabetes & Endocrine Services,Oaklands Park,South Australia,Australia,5046 [59]Box Hill Hospital,Box Hill,Victoria,Australia,3128 [60]Emeritus Research,Camberwell,Victoria,Australia,3124 [61]Austin Health - Repatriation Hospital,Heidelberg West,Victoria,Australia,3081 [62]Baker Heart and Diabetes Institute,Melbourne,Victoria,Australia,3004 [63]Advara HeartCare Joondalup,Joondalup,Western Australia,Australia,6027 [64]Centro de Pesquisa Clinica do Brasil,Brasilia,Distrito Federal,Brazil,71625-175 [65]Cendi - Endocrinologia e Diabetes,Goiânia,Goiás,Brazil,74230-035 [66]Instituto Lóbus,Volta Redonda,Rio De Janeiro,Brazil,27253-003 [67]Instituto Méderi de Pesquisa e Saúde,Passo Fundo,Rio Grande Do Sul,Brazil,99010-120 [68]Instituto de Pesquisa clinica de Campinas,Campinas,São Paulo,Brazil,13060-080 [69]Centro de Pesquisa Clínica de Marília - CPCLIM,Marília,São Paulo,Brazil,17504-072 [70]Pesquisare Saude,Santo André,São Paulo,Brazil,09080-110 [71]CEPIC - Centro Paulista de Investigação Clínica,São Paulo,Brazil,04266-010 [72]Chinese PLA General Hospital,Beijing,Beijing,China,100853 [73]Chongqing General Hospital,Chongqing,Chongqing,China,400014 [74]Hainan General Hospital,Haikou,Hainan,China,570311 [75]The Fourth Hospital of Harbin Medical University,Harbin,Heilongjiang,China,150001 [76]The First Affiliated Hospital of Henan University of Science &Technology,Luoyang Shi,Henan,China,471003 [77]The Second Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan,China,450014 [78]Nanjing First Hospital,Nanjing,Jiangsu,China,210006 [79]The Second Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu,China,210011 [80]Nantong First People's Hospital,Nantong,Jiangsu,China,226001 [81]Dalian Municipal Central Hospital Affiliated of Dalian Medical University,Dalian,Liaoning,China,116033 [82]Jinan Central Hospital,Jinan,Shandong,China,250013 [83]Tianjin Medical University General Hospital,Tianjin,Tianjin,China,300052 [84]Tianjin Medical University Zhu Xianyi Memorial Hospital,Tianjin,Tianjin,China [85]The First People's Hospital of Yunnan Province,Kunming,Yunnan,China,650034 [86]MUDr. Alena Vachova,Ceske Budejovice,Jihočeský,Czechia,37011 [87]MUDr. Tomas Edelsberger,Krnov,Moravskosl,Czechia,79401 [88]Diahelp s.r.o,Pardubice V,Pardubice,Czechia,530 02 [89]Dialine - Interni a diabetologicka ambulance,Pilsen,Plzeň-město,Czechia,301 00 [90]Diabet2 s.r.o., diabetologicka a interni ambulance,Praha,Praha 1,Czechia,11000 [91]Milan Kvapil s.r.o., Diabetologicka ambulance,Praha,Praha 4,Czechia,14900 [92]ResTrial s.r.o.,Praha,Praha 8,Czechia,18100 [93]MUDr. Sabina Palova,Jilove u Prahy,Praha-západ,Czechia,252 42 [94]Milan Kvapil s.r.o., Diabetologicka ambulance Pribram,Pribram,Středočeský Kraj,Czechia,26201 [95]Endokrinologie MUDr. Rehorkova s.r.o.,Hradec Kralove,Czechia,500 12 [96]MUDr. Jitka Zemanová - diabetologie a interna s.r.o.,Plzen,Czechia,326 00 [97]Nemocnice Cesky Krumlov, a.s.,Český Krumlov,Czechia,381 01 [98]CDG Studienambulanz Hartard,München,Bayern,Germany,80809 [99]Gemeinschaftspraxis Dr. med. Josef und Wilma Großkopf,Wallerfing,Bayern,Germany,94574 [100]Diabetes Zentrum Dr. Tews,Gelnhausen,Hessen,Germany,63571 [101]Diabetologische Schwerpunktpraxis Marck Linn Pickel,Pohlheim,Hessen,Germany,35415 [102]InnoDiab Forschung Gmbh,Essen,Nordrhein-Westfalen,Germany,45136 [103]Medizentrum Essen Borbeck,Essen,Nordrhein-Westfalen,Germany,45355 [104]Universitaetsklinikum Koeln,Köln,Nordrhein-Westfalen,Germany,50937 [105]Institut für Diabetesforschung GmbH Münster,Münster,Nordrhein-,Germany,48145 [106]Gemeinschaftspraxis Dr. med. Ralf Denger und Dr. med. Thomas Pfitzner,Friedrichsthal,Saarland,Germany,66299 [107]SMO.MD GmbH,Magdeburg,Sachsen-Anhalt,Germany,39120 [108]AmBeNet GmbH,Leipzig,Sachsen,Germany,04107 [109]Arztpraxis Christine Kosch Pirna,Pirna,Sachsen,Germany,01796 [110]Universität zu Lübeck - Institut für Endokrinologie und Diabetes,Lübeck,Schleswig-Holstein,Germany,23562 [111]RED-Institut GmbH,Oldenburg,Schleswig-Holstein,Germany,23758 [112]Diabetes Zentrum Wilhelmsburg,Hamburg,Germany,21109 [113]Hausarzt- und Diabetologische Schwerpunktpraxis Hohenmölsen - Weiβenfels,Hohenmölsen,Germany,06679 [114]Athens Medical Center,Athens,Attikí,Greece,151 25 [115]Hippokration University Hopsital,Thessaloniki,Kentrikí Makedonía,Greece,54642 [116]Euromedica General Clinic of Thessaloniki,Thessaloniki,Thessaloníki,Greece,546 45 [117]424 Military General Training Hospital,Thessaloniki,Thessaloníki,Greece,564 29 [118]Papageorgiou General Hospital of Thessaloniki,Thessaloniki,Thessaloníki,Greece,564 29 [119]Thermi Clinic,Thessaloniki,Thessaloníki,Greece,570 01 [120]University General Hospital of Larissa,Larissa,Greece,41110 [121]Shree Krishna Hospital,Karamsad,Gujarat,India,388325 [122]Medstar Speciality Hospital,Bangalore,Karnataka,India,560092 [123]Karnataka Institute of Medical Sciences,Hubli,Karnataka,India,580021 [124]TOTALL Diabetes Hormone Institute,Indore,Madhya Pradesh,India,452010 [125]Government Medical College, Aurangabad,Aurangabad,Maharashtra,India,431001 [126]Topiwala National Medical College & B. Y. L. Nair Charitable Hospital,Mumbai,Maharashtra,India,400008 [127]BSES MG Hospital,Mumbai,Maharashtra,India,400058 [128]All India Institute of Medical Sciences (AIIMS) - Nagpur,Nagpur,Maharashtra,India,441108 [129]Sahyadri Super Speciality Hospital,Pune,Maharashtra,India,411004 [130]Arthur Asirvatham Hospital,Madurai,Tamil Nadu,India,625020 [131]Kumudini Devi Diabetes Research Center,Hyderabad,Telangana,India,500072 [132]Fortis Hospital,Noida,Uttar Pradesh,India,201301 [133]Wonju Severance Christian Hospital,Wonju,Kang-won-do,Korea, Republic of,26426 [134]Seoul National University Bundang Hospital,Seongnam,Kyǒnggi-do,Korea, Republic of,13620 [135]Yeungnam Univeristy Medical Center,Gyeongsan-si,Kyǒngsangbuk-do,Korea, Republic of,42415 [136]Advanced Clinical Research, LLC,Bayamón,Puerto Rico,00960 [137]Isis Clinical Research Center,Guaynabo,Puerto Rico,00970

研究目的:
This study will investigate the safety and efficacy of once daily oral treatment with orforglipron compared with placebo on body weight in adult participants with obesity or overweight and type 2 diabetes. The study will last about 77 weeks and may include up to 22 visits.

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