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A Study of Retatrutide (LY3437943) Once Weekly in Participants Who Have Obesity or Overweight and Osteoarthritis of the Knee

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研究单位: [1]Eli Lilly and Company [2],Spain,15006 [3],Spain,15405 [4],Spain,08041 [5]Arizona Research Center,Phoenix,Arizona,United States,85053 [6]Artemis Institute for Clinical Research,San Diego,California,United States,92103 [7]Chase Medical Research, LLC,Waterbury,Connecticut,United States,06708 [8]Suncoast Research Group,Miami,Florida,United States,33135 [9]North Georgia Clinical Research,Woodstock,Georgia,United States,30189 [10]Elite Clinical Trials,Blackfoot,Idaho,United States,83221 [11]Northwestern University,Chicago,Illinois,United States,60611 [12]MedVadis Research Corporation,Waltham,Massachusetts,United States,02451 [13]Great Lakes Research Group, Inc.,Bay City,Michigan,United States,48706 [14]Clinvest Research LLC,Springfield,Missouri,United States,65807 [15]Mercy Family Clinic,Dallas,Texas,United States,75211 [16]Clinical Trials of Texas, Inc.,San Antonio,Texas,United States,78229 [17]Northwest Clinical Research Center,Bellevue,Washington,United States,98007 [18]Paratus Clinical Research Canberra,Bruce,Australian Capital Territory,Australia,2617 [19]Paratus Clinical Research Western Sydney,Blacktown,New South Wales,Australia,2148 [20]Emeritus Research,Botany,New South Wales,Australia,2019 [21]Royal Brisbane and Women's Hospital,Brisbane,Queensland,Australia,4029 [22]Core Research Group,Brisbane,Queensland,Australia,4064 [23]CDH Research Institute,Maroochydore,Queensland,Australia,4558 [24]Emeritus Research,Camberwell,Victoria,Australia,3124 [25]Barwon Health,Geelong,Victoria,Australia,3220 [26]Advara HeartCare Joondalup,Joondalup,Western Australia,Australia,6027 [27]C-health Research,Calgary,Alberta,Canada,T2V 4J2 [28]Eastern Health - General Hospital,St. John's,Newfoundland and Labrador,Canada,A1B 3V6 [29]Viable Clinical Research,Bridgewater,Nova Scotia,Canada,B4V 3N2 [30]Bluewater Clinical Research Group Inc.,Sarnia,Ontario,Canada,N7T 4X3 [31]Viable Clinical Research,Scarborough,Ontario,Canada,M1P 2T7 [32]Stouffville Medical Centre,Stouffville,Ontario,Canada,L4A 1H2 [33]Private Practice - Dr. Pierre Bonin,Sudbury,Ontario,Canada,P3A 1Y8 [34]Canadian Phase Onward,Toronto,Ontario,Canada,M3J 0K2 [35]Alpha Recherche Clinique,Quebec,Canada,G2J 0C4 [36]ALPHA Recherche Clinique,Quebec,Canada,G3K 2P8 [37]Chinese PLA General Hospital,Beijing,Beijing,China,100853 [38]Shunde Hospital of Southern Medical Univesity,Foshan,Guangdong,China,528399 [39]Cangzhou People's Hospital Medical College,Cangzhou,Hebei,China,061600 [40]The First Affiliated Hospital of Henan University of Science &Technology,Luoyang,Henan,China,471003 [41]Baotou Central Hospital,Baotou,Inner Mongolia,China,014040 [42]Nanjing First Hospital,Nanjing,Jiangsu,China,210006 [43]The Second Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu,China,210011 [44]Affiliated Hospital of Jiangsu University,Zhenjiang,Jiangsu,China,212000 [45]The First Hospital of Jilin University,Changchun,Jilin,China,130021 [46]The Fourth Hospital of Harbin Medical University,Harbin,Nangang District,China,150001 [47]The First Affiliated Hospital of Xi'an Medical University,Xi'an,Shaanxi,China,710077 [48]Jinan Central Hospital,Jinan,Shandong,China,250013 [49]Shanghai Minhang District Central Hospital,Shanghai,Shanghai,China,201199 [50]Jiading District Central Hospital,Shanghai,Shanghai,China,201800 [51]West China Hospital of Sichuan University,Chengdu,Sichuan,China,610041 [52]Tianjin Medical University General Hospital,Tianjin,Tianjin,China,300052 [53]The First People's Hospital of Yunnan Province,Kunming,Yunnan,China,650034 [54]Zhejiang Provincial People's Hospital,Hangzhou,Zhejiang,China,310014 [55]Consultorio Médico,Guadalajara,Jalisco,Mexico,44210 [56]IMED Internal Medicine Clin Trials,Monterrey,Nuevo León,Mexico,64060 [57]Clínica García Flores SC,Monterrey,Nuevo León,Mexico,64610 [58]Unidad Médica para la Salud Integral,San Nicolás de los Garza,Nuevo León,Mexico,66465 [59]Centro de Estudios de Investigacion Metabolicos y Cardiovasculares, S.C.,Ciudad Madero,Tamaulipas,Mexico,89440 [60]Köhler & Milstein Research,Mérida,Yucatán,Mexico,97070 [61]Investigacion y Biomedicina de Chihuahua,Chihuahua,Mexico,31000 [62]Hu Reina Sofia,Cordoba,Andalucía,Spain,14004 [63]Hospital Quirón Málaga,Málaga,Andalucía,Spain,29004 [64]Hospital Universitario Infanta Sofía,San Sebastián de Los Reyes,Madrid, Comunidad De,Spain,28702 [65]Hospital General Universitario de Valencia,Valencia,Valenciana, Comunitat,Spain,46014 [66]Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE),Sevilla,Spain,41003 [67]Leicester General Hospital,Leicester,Leicestershire,United Kingdom,LE5 4PW [68]Panthera Biopartners - North London,Enfield Town,London, City Of,United Kingdom,EN3 4GS [69]Panthera Biopartners - Sheffield,Sheffield,United Kingdom,S2 5FX

研究目的:
The main purpose of this study is to evaluate the safety and efficacy of retatrutide once-weekly in participants who have obesity or are overweight and have osteoarthritis (OA) of the knee. The study will lasts about 77 weeks.

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