Evaluation of the Effect of Injectable Neucardin on Cardiac Function and Reversal Ventricular Remodeling in Patients With Chronic Systolic Heart Failure
研究单位：[1]Zensun Sci. & Tech. Co., Ltd.[2]Chinese Academy of Medical Sciences, Fuwai Hospital[3]Beijing Chaoyang Hospital affiliated to Capital Medical University[4]Beijing Chao-Yang Hospital , Capital Medical University,Beijing,Beijing,China,100037[5]Beijing Anzhen Hospital , Capital Medical University,Beijing,Beijing,China[6]Beijing Friendship Hospital , Capital Medical University,Beijing,Beijing,China[7]Peking University First Hospital,Beijing,Beijing,China[8]Peking University People's Hospital,Beijing,Beijing,China[9]The First Medical Center of General Hospital of Chinese People's Liberation Army,Beijing,Beijing,China[10]Fuwai Hospital Chinese Academy of Medical Sciences,Beijin,Beijing,China,100037[11]Chongqing Emergency Medical Center (Chongqing Fourth People's Hospital),Chongqing,Chongqing,China[12]Chongqing University Three Gorges Hospital,Chongqing,Chongqing,China[13]Longyan First Hospital,Longyan,Fujian,China[14]Xiamen University Affiliated Cardiovascular Hospital,Xiamen,Fujian,China[15]First Affiliated Hospital of Sun Yat-sen University,Guangzhou,Guangdong,China[16]Guangdong Jieyang People's Hospital,Jieyang,Guangdong,China[17]Liuzhou worker's hospital,Liuzhou,Guangxi Zhuang Autonomous Region,China[18]People's Hospital of Guangxi Zhuang Autonomous Region,Nanning,Guangxi Zhuang Autonomous Region,China[19]Haikou People's Hospital,Haikou,Hainan,China[20]Hainan Provincial People's Hospital,Haikou,Hainan,China[21]Affiliated Hospital of Hebei University,Baoding,Hebei,China[22]The First Hospital of Hebei Medical University,Shijiazhuang,Hebei,China[23]Daqing Oilfield General Hospital,Daqing,Heilongjiang,China[24]The First Affiliated Hospital of Harbin Medical University,Ha'erbin,Heilongjiang,China[25]Anyang People's Hospital (Anyang Central Hospital),Anyang,Henan,China[26]Huaihe Hospital of Henan University,Kaifeng,Henan,China[27]First Affiliated Hospital of Henan University of Science and Technology,Luoyang,Henan,China[28]Luoyang Central Hospital,Luoyang,Henan,China[29]Nanyang Central Hospital,Nanyang,Henan,China[30]Nanyang First People's Hospital,Nanyang,Henan,China[31]General Hospital of Puyang Oilfield,Puyang,Henan,China[32]Sanmenxia Central Hospital,Sanmenxia,Henan,China[33]First People's Hospital of Shangqiu,Shangqiu,Henan,China[34]The First Affiliated Hospital of Xinxiang Medical College,Xinxiang,Henan,China[35]First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan,China[36]Chenzhou First People's Hospital,Chenzhou,Huanan,China[37]People's Hospital of Wuhan University,Wuhan,Hubei,China[38]Zhongnan Hospital of Wuhan University,Wuhan,Hubei,China[39]Xiangyang Central Hospital,Xiangyang,Hubei,China[40]People's Hospital of Hunan Provincial,Changsha,Hunan,China[41]South China University Affiliated South China Hospital,Hengyang,Hunan,China[42]The Second Affiliated Hospital of Nanhua University,Hengyang,Hunan,China[43]Yueyang Central Hospital,Yueyang,Hunan,China[44]Jiangxi Provincial People's Hospital,Nanchang,Jiangxi,China[45]Changzhou No.2 People's Hospital,Changzhou,Jiansu,China[46]Huai'an First People's Hospital,Huai'an,Jiansu,China[47]The Second Affiliated Hospital of Nanjing Medical University,Nanjing,Jiansu,China[48]Zhongda Hospital Southeast University,Nanjing,Jiansu,China[49]The First Affiliated Hospital of Soochow University,Suzhou,Jiansu,China[50]Affiliated Hospital of Xuzhou Medical University,Xuzhou,Jiansu,China[51]China-Japan Union Hospital of Jilin University,Changchun,Jilin,China[52]Jilin University Second Hospital,Changchun,Jilin,China[53]The First Hospital of Jilin University,Changchun,Jilin,China[54]Benxi Central Hospital,Benxi,Liaoning,China[55]The First Affiliated Hospital of Dalian Medical University,Dalian,Liaoning,China[56]Zhongshan Hospital Affiliated to Dalian University,Dalian,Liaoning,China[57]Shengjing Hospital of China Medical University,Shenyang,Liaoning,China[58]The First Hospital of China Medical University,Shenyang,Liaoning,China[59]Heze Municipal Hospital,Heze,Shandong,China[60]Jinan Central Hospital,Jinan,Shandong,China[61]Qilu Hospital of Shandong University,Jinan,Shandong,China[62]Shandong Province Qianfoshan Hospital,Jinan,Shandong,China[63]Linyi People's Hospital,Linyi,Shandong,China[64]Tai'an City Central Hospital,Tai'an,Shandong,China[65]Zibo Municipal Hospital,Zibo,Shandong,China[66]Putuo District Central Hospital of Shanghai,Shanghai,Shanghai,China[67]Shanxi Provincial Cardiovascular Hospital,Taiyuan,Shanxi,China[68]The First Hospital of Shanxi Medical University,Taiyuan,Shanxi,China[69]The First Affiliated Hospital of Xi 'an Jiaotong University,Xi'an,Shanxi,China[70]Xi'an Gaoxin Hospital,Xi'an,Shanxi,China[71]Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine,Xianyang,Shanxi,China[72]Xianyang Hospital of Yan 'an University,Xianyang,Shanxi,China[73]Mianyang Central Hospital,Mianyang,Sichuan,China[74]The First Affiliated Hospital of Dali University,Dali,Yunnan,China[75]Fuwai Yunnan Cardiovascular Hospital,Kunming,Yunnan,China[76]The First People's Hospital of Yunnan Province,Kunming,Yunnan,China[77]The First Affiliated Hospital , Zhejiang University School of Medicine,Hangzhou,Zhejiang,China[78]The Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou,Zhejiang,China[79]Affiliated Hospital of Hangzhou Normal University,Hanzhou,Zhejiang,China[80]Sir Run Run Shaw Hospital,Hanzhou,Zhejiang,China[81]Jiaxing First Hospital,Jiaxing,Zhejiang,China[82]Ningbo Huamei Hospital, University of Chinese Academy of Sciences (Ningbo Second Hospital),Ningbo,Zhejiang,China[83]The First Hospital of Ningbo,Ningbo,Zhejiang,China
A multicenter, randomized, double-blind, placebo-controlled phase III clinical trial to evaluate the effect of recombinant human Neuregulin-1 for injection on cardiac function and reverse ventricular remodeling in male patients with NT-proBNP ≤ 1700 pg/ml and female patients with NT-proBNP ≤ 4000 pg/ml and New York Heart Association class II-III chronic systolic heart failure, and to confirm its efficacy and safety.
