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一项旨在检测不同剂量BI 456906对非酒精性脂肪性肝炎(NASH)和肝纤维化患者是否有效的研究

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研究单位: [1]北京清华长庚医院 [2]首都医科大学附属北京友谊医院 [3]首都医科大学附属北京佑安医院 [4]浙江大学医学院附属第一医院 [5]云南省第一人民医院 [6]浙江大学医学院附属邵逸夫医院 [7]首都医科大学附属北京地坛医院 [8]北京大学人民医院 [9]吉林大学第一医院 [10]温州医科大学附属第一医院 [11]上海市公共卫生临床中心 [12]中山大学附属第一医院 [13]天津市第三中心医院 [14]南方医科大学南方医院 [15]南京市第二医院 [16]Gold Coast University Hospital [17]Royal Melbourne Hospital [18]Monash Medical Centre [19]Royal Perth Hospital [20]LKH-Univ. Hospital Graz [21]Medical University of Innsbruck [22]Edegem - UNIV UZ Antwerpen [23]AZ Maria Middelares [24]ECOGENE-21 [25]Toronto Liver Centre [26]University Hospital (LHSC) [27]Regional Hospital Liberec [28]General Faculty Hospital,Prague [29]Institute for Clinical and Experimental Medicine [30]HOP La Pitié Salpêtrière [31]HOP Haut-Lévêque [32]HOP Hautepierre [33]HOP l'Archet [34]Universitatsmedizin der Johannes Gutenberg-Universitat Mainz [35]Universitatsklinikum Ulm [36]Universitatsklinikum Leipzig [37]Universitatsklinikum Aachen,AoR [38]Universitatsklinikum Düsseldorf [39]Universitatsklinikum Knappschaftskrankenhaus Bochum GmbH [40]Universitatsklinikum Mannheim GmbH [41]Universitatsmedizin Gottingen,Georg-August-Universitat [42]General Hospital of Thessaloniki [43]General Hospital of Thessaloniki [44]General Oncology Hospital [45]Hippokration General Hospital of Athen [46]General Hospital of Athens [47]Attikon University Hospital [48]Queen Mary Hospital [49]Prince of Wales Hospital [50]Fed.St. Istvan&Szent Laszlo Hospital [51]Bekes County Central Hospital [52]Sourasky Medical Center [53]Western Galilee Hospital [54]Shaare Zedek Medical Center,Jerusalem 91031 [55]Rambam Medical Center [56]The Chaim Sheba Medical Center [57]Rabin Medical Center Beilinson [58]Lady Davis Carmel Medical Center,Haifa 34362 [59]Haemek Medical Center [60]AO Città della Salute e della [61]A.O. Univ. Policlinico [62]IRCCS Ospedale [63]Policlinico Gemelli [64]Istituto Clinico Humanitas [65]Yokohama City University Hospital [66]Saga University Hospital [67]Kumamoto University Hospital [68]Niigata University Medical and Dental Hospital [69]Ogaki Municipal Hospital [70]University Hospital Kyoto Prefectural University of Medicine [71]Juntendo University Shizuoka Hospital [72]Kurume University Hospital [73]Fukuiken Saiseikai Hospital [74]Fukuoka University Hospital [75]Kitasato University Hospital [76]Nagano Municipal Hospital [77]National Hospital Organization Yokohama Medical Center [78]Hamamatsu University Hospital [79]Nara Medical University Hospital [80]St. Marianna University School of Medicine Hospital [81]Suita Hospital [82]Tokyo Medical and Dental University [83]Shinshu University Hospital [84]Kagawa University Hospital [85]Japan Community Health Care Organization Hokkaido Hospital [86]Ehime University Hospital [87]Seoul National University Hospital [88]Pusan National Univ. Hosp [89]Hanyang University Medical Center [90]University of Malaya Medical Centre [91]Hospital Selayang [92]Hospital Serdang [93]Sint Franciscus,Locatie Vlietland [94]Amsterdam UMC,Locatie AMC [95]Leids Universitair Medisch Centrum (LUMC) [96]Auckland Clinical Studies Ltd [97]Middlemore Hospital,Auckland [98]ETG Zamosc [99]University Clinical Center Professor Gibinskiego [100]University Hospital [101]Medicome Limited Liability Company [102]Pratia SA [103]Melita Medical Medical Center [104]Private health care facility [105]INTERCORE Medical Center [106]CHULN,EPE - Hospital de Santa Maria [107]CHTAD,EPE - Hospital Sao Pedro de Vila Real [108]Centro Hospitalar Universitário Sao Joao,EPE [109]Hospital Senhora Oliveira Guimaraes,EPE [110]Singapore General Hospital [111]National University Hospital [112]Changi General Hospital [113]Hospital Virgen del Rocío [114]Hospital Universitario Marqués de Valdecilla [115]Hospital Puerta de Hierro [116]Hospital Vall d'Hebron [117]Hospital General Universitario de Valencia [118]National Chen Kung University,Dept of Neurology [119]Kaohsiung Medical University Chung-Ho Memorial Hospital [120]Chang Gung Memorial Hospital(Linkou) [121]Chia Yi Christian Hospital [122]National Taiwan University Hospital [123]Queen Elizabeth Hospital [124]King's College Hospital [125]Aintree University Hospital [126]Addenbrooke's Hospital [127]Queen's Medical Centre [128]Southern California Gastrointestinal and Liver Centers [129]Sanchez Clinical Research,Inc [130]Tandem Clinical Research [131]NECCR PrimaCare Research,LLC [132]American Research Corporation at the Texas Liver Institute [133]Lucas Research,Inc. [134]Northwell Health [135]Quest Clinical Research [136]Centex Studies,Inc. [137]Omega Research Orlando,LLC [138]Centex Studies,Inc. [139]Covenant Research [140]Houston Methodist Hospital [141]Office of Dr. Franco Felizarta [142]National Research Institute [143]Virginia Commonwealth University [144]Texas Clinical Research Institute,LLC [145]University of Iowa Hospitals and Clinics [146]National Research Institute [147]Ocala GI Research [148]Digestive Health Research of Southern CA [149]AIG Digestive Disease Research [150]Gastrointestinal Specialists of Georgia [151]Northeast GI Research Division [152]South Texas Research Institute [153]Digestive Research Alliance of Michiana [154]North Alabama Health Research,LLC [155]Digestive Diseases Research Center [156]Palmetto Clinical Research [157]Pinnacle Clinical Research [158]Peak Gastroenterology Associates [159]National Diabetes and Obesity Research Institute [160]Gastrointestinal Associates [161]University of California San Diego [162]Delta Research Partners,LLC [163]Digestive Health Research [164]Covenant Research and Clinics,LLC [165]Optimus U Corporation

研究目的:
试验的主要目的是证明非平坦的剂量反应曲线,以评价治疗效应的大小(使用第48周时BI 456906和安慰剂之间组织学改善患者比例的绝对差异)并描述剂量-反应关系。

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