Problem: Immune tolerance with respect to a semi-allogeneic fetus plays a key role in
the establishment of a pregnancy. Memory T follicular helper (Tfh) cells have a central
role in the regulation of the adaptive immune response. Much of our knowledge of
memory Tfh cells’ function comes from immune-related diseases. However, the true
physiological characteristics of memory Tfh cells and their mode of action in pregnancy remain unclear.
Methods of study: Deciduas and blood were obtained from 25 recurrent spontaneous
abortion (RSA) patients undergoing surgical abortion and 19 normal women in early
pregnancy undergoing elective termination. RSA patients were grouped into antibodypositive patients and antibody-negative patients, respectively. The memory Tfh cells
with the CD4+
CXCR5+
PD1+
CCR7−
and CD4+
CXCR5+
PD-1+
ICOS+
phenotypes were
assessed by flow cytometry. The B cells were evaluated by flow cytometry. A correlation analysis of the subsets of memory Tfh cells and B cells in antibody-positive RSA
patients was made by the Pearson test.
Results: Memory Tfh cells with the CD4+
CXCR5+
PD1+
CCR7−
and CD4+
CXCR5+
PD-
1+
ICOS+ phenotypes showed a significant increase in RSA patients compared to
women with a normal pregnancy who had chosen termination. When RSA patients
were grouped according positive or negative antibodies, it was surprising to find that
decidual CD4+
CXCR5+
PD-1+
ICOS+ memory Tfh cells significantly increased in RSA
patients with positive antibody compared to RSA patients with negative antibody.
However, the percentages of CD4+
CXCR5+
PD1+
CCR7−
memory Tfh cells did not
change in the deciduas of the two groups. Circulating and decidual B cells significantly
increased in antibody-positive RSA patients compared with antibody-negative RSA
patients. Correlation analysis indicated a strong association between the decidual
CD4+
CXCR5+
PD-1+
ICOS+ memory Tfh cells and B cells in antibody-positive RSA
patients.
Conclusion: These new findings provide unique insights into memory Tfh cells in
mediating feto-maternal immune tolerance.
语种：
外文
中科院(CAS)分区：
出版当年[2017]版：
大类|2 区医学
小类|2 区生物工程与应用微生物2 区细胞与组织工程2 区细胞生物学2 区血液学2 区肿瘤学
最新[2023]版：
大类|2 区医学
小类|2 区生物工程与应用微生物2 区血液学3 区细胞与组织工程3 区细胞生物学3 区肿瘤学
第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Xiaorui Luan,Weiping Li.An investigation of the relationship between recurrent spontaneous abortion and memory T follicular helper cells[J].WILEY.2017,78(5):1-9.doi:10.1111/aji.12714.
APA：
Xiaorui Luan&Weiping Li.(2017).An investigation of the relationship between recurrent spontaneous abortion and memory T follicular helper cells.WILEY,78,(5)
MLA：
Xiaorui Luan,et al."An investigation of the relationship between recurrent spontaneous abortion and memory T follicular helper cells".WILEY 78..5(2017):1-9
