Metabolic Encephalopathy mainly refers to a group of diseases in which biochemical metabolic changes in the body cause changes in the environment of brain tissue, resulting in brain dysfunction. For the post-operative patients who underwent radical pancreaticod- uodenectomy combined with left hemihepatectomy in Hepatobiliary Pancreatic Surgery, such as severe trauma, many postoperative complications and long fasting time, the probability of metabolic encephalopathy is higher. A case of metabolic encephalopathy after radical pancreaticoduodenectomy combined with left hemihepatectomy in our hospital is analyzed as follows.