机构：[1]School of Medicine, Kunming University of Science and Technology[2]Yunnan Digestive Endoscopy Clinical Medical Center, Department of Gastroenterology, The First People's Hospital of Yunnan Province, Affiliated by Kunming University of Science and Technology[3]Yunnan Province Clinical Research Center for Senile Diseases, First People's Hospital of Yunnan Province[4]Yunnan Institute of Food and Drug Supervision and Control, Medical Products Administration of Yunnan Province[5]State Key Laboratory of Respiratory Disease, Guangzhou Medical University[6]Guangdong-Hongkong-Macao Joint Laboratory of Respiratory Infectious Disease, Guangzhou Medical University[7]Yunnan Provincial Key Laboratory of Clinical Virology, The First People's Hospital of Yunnan Province[8]Yunnan Provincial Key Laboratory of Birth Defects and Genetic Diseases, First People's Hospital of Yunnan Province
Dietary behaviors significantly influence tumor progression, with increasing
focus on high-salt diets (HSD) in recent years. Traditionally, HSD has been regarded
as a major risk factor for multiple health issues, including hypertension,
cardiovascular disease, kidney disease, cancer, and osteoporosis. However, recent
studies have uncovered a novel aspect of HSD, suggesting that HSD may inhibit
tumor growth in specific pathological conditions by modulating the activity of
immune cells that infiltrate tumors and enhancing the effectiveness of PD-1
immunotherapy. This review focused on the duel molecular mechanisms of HSD in
cancer development, which are based on the tumor microenvironment, the gut
microbiota, and the involvement of sodium transporter channels. The objective of this
review is to explore whether HSD could be a potential future oncological therapeutic
strategy under specific situation
基金：
National Natural Science Foundation of China(82460111, 82260483),the Yunnan Province Famous Doctor program(KH-SWR-MY-2018-020), the The First People’s Hospital of Yunnan Province Talent Project program(KHBS-2022013, KHYJ-2023-05-01, 2022-KHRCBZ-B03),the Kunming Medical University Joint Special Project on Applied Basic Research(202301AY070001-007,-210),Yunnan Foundmental basical research project(202301AT070034, 202301AS070015),Yunnan Province Clinical Research Center for Senile diseases Open project(2023YJZX-LN03,-13 of 202102AA310069)
语种：
外文
中科院(CAS)分区：
出版当年[2025]版：
无
最新[2023]版：
大类|2 区医学
小类|2 区免疫学
第一作者：
第一作者机构：[1]School of Medicine, Kunming University of Science and Technology
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Shiwei Tang,Juan Xu,Ping Wan,et al.Recent advances in the role of high-salt diet in anti- and pro-cancer progression[J].Frontiers in immunology.2025,(16):doi: 10.3389/fimmu.2025.1542157.
APA：
Shiwei Tang,Juan Xu,Ping Wan,Shumen Jin,Ying Zhang...&Zan Zuo.(2025).Recent advances in the role of high-salt diet in anti- and pro-cancer progression.Frontiers in immunology,,(16)
MLA：
Shiwei Tang,et al."Recent advances in the role of high-salt diet in anti- and pro-cancer progression".Frontiers in immunology ..16(2025)
