Oncogenic Role of Heterogeneous Nuclear Ribonucleoprotein C in Multiple Cancer Types, with a Particular Focus on Lung Adenocarcinoma, Using a Pan-Cancer Analysis and Cell Line Experiments
机构：[1]Thoracic Surgery Department, Yan'an Hospital affiliated to Kunming Medical University, Kunming 650031, China.[2]Thoracic Surgery Department, The First People's Hospital of Yunnan Province, Kunming 650031, China.外科片胸外科云南省第一人民医院[3]Cardiovascular Surgery Department, The First People's Hospital of Yunnan Province, Kunming 650031, China.外科片心脏大血管外科云南省第一人民医院
Although some evidence has validated the connection between heterogeneous nuclear ribonucleoprotein C (HNRNPC) and the progression of tumors, a pan-cancer investigation is still required. Thus, we explored the oncogenic effect of HNRNPC across many tumors using The Cancer Genome Atlas datasets. Moreover, short hairpin RNAs (shRNAs) were found to repress HNRNPC in lung adenocarcinoma (LUAD) cells, and the effect on LUAD cells proliferation and metastasis was examined using a Cell Counting Kit-8, transwell, and invasion test. HNRNPC was found to be overexpressed in most cancers, and a divergent relationship was observed between the abnormal levels of HNRNPC and tumor prognosis. HNRNPC level was observed to correlate with the cancer-associated fibroblast infiltration, such as lung cancer. Furthermore, higher HNRNPC levels were found in LUAD tissues and cells. Subsequently, Kaplan-Meier analysis revealed that the increased HNRNPC level was connected with worse overall survival and disease-free survival in LUAD patients. Moreover, HNRNPC silencing reduced the progression of A549 and H1299 cells, including proliferation, migration, and invasion. This is the first pan-cancer investigation that presents a relatively systematic finding of the oncogenic effect of HNRNPC among many cancer types. Our data indicate that HNRNPC facilitates the biological processes of LUAD cells; nevertheless, further research on the mechanism underlying the role of HNRNPC in LUAD development is warranted.
基金：
the Medical and Health Unit with Research Institutions of Scientific Research Projects in Yunnan Province (No. 2018NS0271).
第一作者机构：[1]Thoracic Surgery Department, Yan'an Hospital affiliated to Kunming Medical University, Kunming 650031, China.
通讯作者：
通讯机构：[3]Cardiovascular Surgery Department, The First People's Hospital of Yunnan Province, Kunming 650031, China.[*1]Cardiovascular Surgery Department, The First People’s Hospital of Yunnan Province, Kunming 650031, China
推荐引用方式(GB/T 7714)：
Zhang Libin,Peng Hao,Jiang Lihong.Oncogenic Role of Heterogeneous Nuclear Ribonucleoprotein C in Multiple Cancer Types, with a Particular Focus on Lung Adenocarcinoma, Using a Pan-Cancer Analysis and Cell Line Experiments[J].JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY.2022,41(3):doi:10.1615/JEnvironPatholToxicolOncol.2022042822.
APA：
Zhang Libin,Peng Hao&Jiang Lihong.(2022).Oncogenic Role of Heterogeneous Nuclear Ribonucleoprotein C in Multiple Cancer Types, with a Particular Focus on Lung Adenocarcinoma, Using a Pan-Cancer Analysis and Cell Line Experiments.JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY,41,(3)
MLA：
Zhang Libin,et al."Oncogenic Role of Heterogeneous Nuclear Ribonucleoprotein C in Multiple Cancer Types, with a Particular Focus on Lung Adenocarcinoma, Using a Pan-Cancer Analysis and Cell Line Experiments".JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY 41..3(2022)
