机构：[1]Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China[2]Department of General Surgery, The First People’s Hospital of Yunnan Province (The Affiliated Hospital of Kunming University of Science and Technology), Kunming, Yunnan Province, China云南省第一人民医院[3]Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang Province, China
Background N6 methyladenosine (m6A) RNA methylation regulators play a key role in the occurrence and development of many tumors. However, the function of N6 methyladenosine (m6A) RNA methylation regulators in pancreatic adenocarcinoma (PAAD) has not been fully clarified. Methods We used data set from GEPIA 2, UALCAN, TIMER, TISIDB, CBioPortal database to analyze the gene expression of 20 major m6A RNA methylation regulators. Results Our study revealed that the irregularity of m6A regulators were associated with poor prognosis in PAAD. Meantime, 13 m6A regulators showed high expression in PAAD samples (ALKBH5, ELAVL1, FTO, HNRNPC, IGF2BP2, METTL14, METTL16 (METT10D), RBM15, VIRMA (KIAA1429), YTHDF1, YTHDF2, YTHDF3 and ZC3H13). In these regulators, we evaluated HNRNPC and IGF2BP2 were significantly correlated with worse outcomes and ALKBH5, IGF2BP2, METTL16 (METT10D), RBM15 were significantly correlated with PAAD in advanced stage. Moreover, we showed m6A regulators is correlated with Immuno-regulators' (Immunoinhibitors, Immunostimulators and MHC molecules) expression and levels of immune infiltration in PAAD. Bioinformatics further demonstrate m6A regulators were participated in revising in RNA processing. Conclusions Our study investigated that the m6A regulatory factors may serve as a biomarker and a potential target of immunotherapy for PAAD.
基金：
Yunnan Digestive Endoscopy Clinical Medical Center Foundation for Health Commission of Yunnan Province [2021LCZXXF-XH10, 2022LCZXKF-XH09, ZX2019-01-02]; Yunnan Fundamental Research Projects [202201AU070031]
第一作者机构：[1]Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Zhang Tao,Sheng Ping,Jiang Yuting.m6A regulators are differently expressed and correlated with immune response of pancreatic adenocarcinoma[J].JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY.2023,149(7):2805-2822.doi:10.1007/s00432-022-04150-7.
APA：
Zhang, Tao,Sheng, Ping&Jiang, Yuting.(2023).m6A regulators are differently expressed and correlated with immune response of pancreatic adenocarcinoma.JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY,149,(7)
MLA：
Zhang, Tao,et al."m6A regulators are differently expressed and correlated with immune response of pancreatic adenocarcinoma".JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 149..7(2023):2805-2822
