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Positive rates of interferon-γ release assay and tuberculin skin test in detection of latent tuberculosis infection: A systematic review and meta-analysis of 200,000 head-to-head comparative tests

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机构: [1]Department of Science and Research, The First People’s Hospital of Anning Affiliated to Kunming University of Science and Technology, Kunming, Yunnan Province 650302, China [2]Department of Medical Imaging, Yan’an Hospital Affiliated to Kunming Medical University, Kunming, Yunnan Province 650051, China [3]State Key Laboratory of Medical Molecular Biology &Department of Immunology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China [4]Department of Pulmonary and Critical Care Medicine, The First People’s Hospital of Anning Affiliated to Kunming University of Science and Technology, Kunming, Yunnan Province 650302, China [5]Department of Endocrinology, The First People’s Hospital of Anning Affiliated to Kunming University of Science and Technology, Yunnan Province 650302, China [6]Division of Tuberculosis Control and Prevention, Yunnan Center for Disease Control and Prevention, Kunming, Yunnan Province 650051, China [7]Department of Hepatology 1, The Third People’s Hospital of Kunming, Kunming 650500, China [8]Department of Urology, Yan’an Hospital Affiliated to Kunming Medical University, Kunming, Yunnan Province 650051, China [9]School of Basic Medical Sciences, Kunming Medical University, Kunming, Yunnan Province 650051, China [10]Department of Medical Imaging, The First People’s Hospital of Anning Affiliated to Kunming University of Science and Technology, Kunming, Yunnan Province 650302, China
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关键词: Latent tuberculosis infection Interferon-γ release assay Tuberculin skin test Positive rate Head-to-head comparison

摘要:
To compare the positive rates of IGRA and TST in detection of LTBI.We searched PubMed, Embase, and the Cochrane Library on March 12, 2022. A random-effects model was used to calculate pooled results.We included 458 head-to-head studies. Compared with immunocompetent controls, TST positive rate in immunosuppressed population decreased more than IGRA positive rate (OR 0.36 [95% CI: 0.31 to 0.41] versus 0.53 [0.46 to 0.61]). In immunocompetent BCG-vaccinated individuals, IGRA positive rate in low-TB burden areas was significantly lower than TST positive rate, but the difference was decreased in high-TB burden areas (OR 0.75 [0.60 to 0.94]). Additionally, IGRA positive rate was equal to that of TST in the elderly (OR 0.98 [0.66 to 1.46]).TST is more susceptible to immunosuppression than IGRA. The effect of BCG on TST might be weakened in high-TB burden areas, and TST response waned in the elderly.PROSPERO CRD42020180163.Copyright © 2022. Published by Elsevier Inc.

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基金编号: Leading talents

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出版当年[2022]版:
大类 | 3 区 医学
小类 | 3 区 免疫学
最新[2025]版:
大类 | 3 区 医学
小类 | 3 区 免疫学
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第一作者机构: [1]Department of Science and Research, The First People’s Hospital of Anning Affiliated to Kunming University of Science and Technology, Kunming, Yunnan Province 650302, China
通讯作者:
通讯机构: [10]Department of Medical Imaging, The First People’s Hospital of Anning Affiliated to Kunming University of Science and Technology, Kunming, Yunnan Province 650302, China [*1]Department of Radiology, The First People’s Hospital of Anning Affiliated to Kunming University of Science and Technology, No.2 Ganghe South Road, Anning City, Kunming City, Yunnan Province 650302, China
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