机构：[1]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China[2]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China[3]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China[4]Frontier Science Center for Immunology and Metabolism, Medical Research Institute, College of Life Sciences, Wuhan University,Wuhan 430071, China[5]CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China NationalCenter for Bioinformation, Beijing 100101, China[6]University of Chinese Academy of Sciences, Beijing 100049, China[7]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China[8]CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences,Shanghai 200031, China[9]CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences,Beijing 100101, China[10]Peking University International Cancer Institute, Peking University Health Science Center, Peking University, Beijing 100191, China[11]School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China[12]State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences,Beijing 100101, China[13]School of Pharmaceutical Sciences, Beijing Advanced Innovation Center for Structural Biology, Ministry of Education Key Laboratory ofBioorganic Phosphorus Chemistry and Chemical Biology, Tsinghua University, Beijing 100084, China[14]Colorectal Cancer Center/Department of Gastrointestinal Surgery, Shanghai Tenth People’s Hospital Affiliated to Tongji University,Shanghai 200072, China[15]Department of Geriatrics, Medical Center on Aging of Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine,Shanghai 200025, China[16]International Laboratory in Hematology and Cancer, Shanghai Jiaotong University School of Medicine/Ruijin Hospital,Shanghai 200025, China[17]Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China[18]State Key Laboratory of Genetic Resources and Evolution/Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Instituteof Zoology, Chinese Academy of Sciences, Kunming 650223, China[19]CAS Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming 650223, China[20]Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Scienceand Technology of China, Hefei 230027, China[21]State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular CellScience, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China[22]Aging and Vascular Diseases, Human Aging Research Institute (HARI) and School of Life Science, Nanchang University, and Jiangxi KeyLaboratory of Human Aging, Nanchang 330031, China[23]Center of Growth, Metabolism and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of LifeSciences, Sichuan University, Chengdu 610065, China[24]Institute of Ageing Research, Hangzhou Normal University, School of Basic Medical Sciences, Hangzhou 311121, China[25]Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu HospitalCapital Medical University, Beijing 100053, China首都医科大学宣武医院[26]Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center,Xuanwu Hospital, Capital Medical University, Beijing 100053, China首都医科大学宣武医院[27]The Fifth People’s Hospital of Chongqing, Chongqing 400062, China[28]MOE Key Laboratory of Cellular Dynamics, Hefei National Research Center for Physical Sciences at the Microscale, CAS Key Laboratory ofBrain Function and Disease, Neurodegenerative Disorder Research Center, School of Life Sciences, Division of Life Sciences and Medicine,University of Science and Technology of China, Hefei 230026, China[29]Guangzhou Laboratory, Guangzhou International Bio Island, Guangzhou 510005, China[30]Department of Medicine and VAPSHCS, University of Washington, Seattle 98195, USA[31]Department of Immunology and Pathology, Monash University Faculty of Medicine, Prahran, Victoria 3181, Australia[32]Hudson Institute of Medical Research, and Monash University Department of Molecular and Translational Science, Clayton, Victoria 3168,Australia[33]Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Center for Quantitative Biology, PekingUniversity, Beijing 100871, China
Aging is characterized by a progressive deterioration of physiological integrity, leading to impaired functional ability and ultimately increased susceptibility to death. It is a major risk factor for chronic human diseases, including cardiovascular disease, diabetes, neurological degeneration, and cancer. Therefore, the growing emphasis on "healthy aging" raises a series of important questions in life and social sciences. In recent years, there has been unprecedented progress in aging research, particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes. In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases, we review the descriptive, conceptual, and interventive aspects of the landscape of aging composed of a number of layers at the cellular, tissue, organ, organ system, and organismal levels.
基金：
National Natural
Science Foundation of China (31871380, 32000500, 32070730, 32170756,
32170804, 81330008, 81671377, 81725010, 81725010, 81872874,
81921006, 81922027, 81971312, 81991512, 82030041, 82103167,
82122024, 82125009, 82125011, 82130044, 91749126, 91949101,
91949207, 92049302), the National Key Research and Development Program
of China (2017YFA0506400, 2018YFA0800200, 2018YFA0800700,
2018YFA0900200, 2018YFC2000100, 2018YFC2000400, 2018YFE-
0203700, 20192ACB70002, 2019YFA0802202, 2020YFA0113400,
2020YFA0803401, 2020YFA0804000, 2020YFC2002800, 2020YFC-
2002900, 2021ZD0202401), the Strategic Priority Research Program of the
Chinese Academy of Sciences (XDA16010100, XDA16010603,
XDA16020400, XDB29020000, XDB39000000, XDB39000000,
XDB39030300), the China Association for Science and Technology
(2021QNRC001), the Beijing Municipal Science and Technology Commission
(Z200022), the Natural Science Foundation of Shanghai
(21JC1406400), the Key Programs of the Jiangxi Province, China
(20192ACB70002), the “Shu Guang” Project supported by the Shanghai
Municipal Education Commission and Shanghai Education Development Foundation (19SG18), the Shanghai Sailing Program (22YF1434300), the
Research Project of Joint Laboratory of University of Science and Technology
of China and Anhui Mental Health Center (2019LH03), the Fundamental
Research Funds for the Central Universities (WK2070210004),
the Young Elite Scientists Sponsorship Program by China Association for
Science and Technology (YESS20210002), and the Youth Innovation Promotion
Association of Chinese Academy of Sciences (2022083).
第一作者机构：[1]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China[2]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China[3]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China
共同第一作者：
通讯作者：
通讯机构：[1]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China[2]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China[3]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China[5]CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China NationalCenter for Bioinformation, Beijing 100101, China[6]University of Chinese Academy of Sciences, Beijing 100049, China[7]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China[8]CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences,Shanghai 200031, China[9]CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences,Beijing 100101, China[12]State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences,Beijing 100101, China[14]Colorectal Cancer Center/Department of Gastrointestinal Surgery, Shanghai Tenth People’s Hospital Affiliated to Tongji University,Shanghai 200072, China[15]Department of Geriatrics, Medical Center on Aging of Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine,Shanghai 200025, China[16]International Laboratory in Hematology and Cancer, Shanghai Jiaotong University School of Medicine/Ruijin Hospital,Shanghai 200025, China[18]State Key Laboratory of Genetic Resources and Evolution/Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Instituteof Zoology, Chinese Academy of Sciences, Kunming 650223, China[19]CAS Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming 650223, China[20]Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Scienceand Technology of China, Hefei 230027, China[24]Institute of Ageing Research, Hangzhou Normal University, School of Basic Medical Sciences, Hangzhou 311121, China[25]Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu HospitalCapital Medical University, Beijing 100053, China[26]Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center,Xuanwu Hospital, Capital Medical University, Beijing 100053, China[27]The Fifth People’s Hospital of Chongqing, Chongqing 400062, China[29]Guangzhou Laboratory, Guangzhou International Bio Island, Guangzhou 510005, China[30]Department of Medicine and VAPSHCS, University of Washington, Seattle 98195, USA[31]Department of Immunology and Pathology, Monash University Faculty of Medicine, Prahran, Victoria 3181, Australia[32]Hudson Institute of Medical Research, and Monash University Department of Molecular and Translational Science, Clayton, Victoria 3168,Australia
推荐引用方式(GB/T 7714)：
Yusheng Cai,Wei Song,Jiaming Li,et al.The landscape of aging[J].SCIENCE CHINA-LIFE SCIENCES.2022,65(12):2354-2454.doi:10.1007/s11427-022-2161-3.
生物学