机构：[1]Department of Gynecology and Obstetrics, The West China Second University Hospital, Sichuan University, 610041 Chengdu, Sichuan, China [2]Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, 610041 Chengdu, Sichuan, China [3]Department of Genetic Diagnosis Center, First People’s Hospital of Yunnan Province, 650032 Kunming, Yunnan, China门急诊片医学遗传科云南省第一人民医院
Objectives: Hypertensive disorders occur in approximately 12% to 22% of pregnancies and cause substantial perinatal morbidity and mortality of both mother and fetus. Hypertensive disease is directly responsible for approximately 20% of maternal deaths and can be classified as chronic hypertension, gestational hypertension, preeclampsia-eclampsia, and chronic hypertension with superimposed preeclampsia. At present, the pathogenesis of preeclampsia is still unclear, we wrote this article to make a uptodate review of this disease. Mechanism: A comprehensive search of several databases was conducted from inception up to March 2022. The searched databases were Web of Science, MEDLINE,Ovid, and Cochrane Database of Systematic Reviews. The search strategy included the combinations of the following medical terms: Hypertensive disorders; preeclampsia; mechanism; pathogenesis hypothesis. Findings in Brief: At present,the pathogenesis of preeclampsia is still unclear, the theory of Genetic,Inflammatory Response, Immune Imbalance in Maternal-Fetal Interface, Oxidative Stress, Vascular Endothelial Cell Damage are supposed involved in the progress of preeclampsia. Conclusions: Although there are various theories mentioned above, none of the hypothesis can fully explain preeclampsia. More research is needed on the mechanism of preeclampsia.
第一作者机构：[1]Department of Gynecology and Obstetrics, The West China Second University Hospital, Sichuan University, 610041 Chengdu, Sichuan, China [2]Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, 610041 Chengdu, Sichuan, China
通讯作者：
通讯机构：[1]Department of Gynecology and Obstetrics, The West China Second University Hospital, Sichuan University, 610041 Chengdu, Sichuan, China [2]Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, 610041 Chengdu, Sichuan, China
推荐引用方式(GB/T 7714)：
Lian Rui,Zhu Bao-Sheng,Zeng Xi.An Update Review of the Pathogenesis Hypothesis in Preeclampsia[J].CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY.2022,49(8):doi:10.31083/j.ceog4908170.
APA：
Lian, Rui,Zhu, Bao-Sheng&Zeng, Xi.(2022).An Update Review of the Pathogenesis Hypothesis in Preeclampsia.CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY,49,(8)
MLA：
Lian, Rui,et al."An Update Review of the Pathogenesis Hypothesis in Preeclampsia".CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY 49..8(2022)
