机构：[1]Department of Ophthalmology, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China[2]National Engineering Laboratory of Southwest Endangered Medicinal Resources Development, Guangxi Botanical Garden of Medicinal Plants, Nanning, Guangxi Zhuang Autonomous Region, China[3]Department of Neurology, the People’s Hospital of Chuxiong Yi Autonomous Prefecture, Chuxiong Yi Autonomous Prefecture, Yunnan Province, China[4]Department of Neurology, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China
Methylprednisolone pulse treatment is currently used for optic neuritis. It can speed visual recovery, but does not improve the ultimate visual outcomes. Recent studies have reported that miR-125a-5p has immunomodulatory effects on autoimmune diseases. However, it remains unclear whether miR-125a-5p has effects on optic neuritis. In this study, we used adeno-associated virus to overexpress or silence miR-125a-5p in mice. We found that silencing miR-125a-5p increased the latency of visual evoked potential and aggravated inflammation of the optic nerve. Overexpression of miR-125a-5p suppressed inflammation of the optic nerve, protected retinal ganglion cells, and increased the percentage of Treg cells. Our findings show that miR-125a-5p exhibits anti-inflammatory effects through promoting the differentiation of Treg cells.
基金：
This work was supported by the National Natural Science Foundation of China, No. 81560162; and the Guangxi Natural Science Foundation of China, No. 2018GXNSFAA050052 (both YD).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类|2 区医学
小类|3 区细胞生物学3 区神经科学
最新[2023]版：
大类|2 区医学
小类|3 区细胞生物学3 区神经科学
第一作者：
第一作者机构：[1]Department of Ophthalmology, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China
通讯作者：
推荐引用方式(GB/T 7714)：
Zhan Jia-Lin,Huang Yan-Ling,Liang Qiao-Wen,et al.Anti-inflammatory effect of miR-125a-5p on experimental optic neuritis by promoting the differentiation of Treg cells[J].Neural Regeneration Research.2023,18(2):451-455.doi:10.4103/1673-5374.346462.
APA：
Zhan Jia-Lin,Huang Yan-Ling,Liang Qiao-Wen,Qu Xiao-Sheng,Dong Zi-Mei...&Luo Wen-Jing.(2023).Anti-inflammatory effect of miR-125a-5p on experimental optic neuritis by promoting the differentiation of Treg cells.Neural Regeneration Research,18,(2)
MLA：
Zhan Jia-Lin,et al."Anti-inflammatory effect of miR-125a-5p on experimental optic neuritis by promoting the differentiation of Treg cells".Neural Regeneration Research 18..2(2023):451-455
