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Neural signatures of default mode network in major depression disorder after electroconvulsive therapy

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Pubmed体系：
作者：
Li Yuanyuan[1,2] * ; Yu Xiaohui[1] ; Ma Yingzi[1] ; Su Jing[1] ; Li Yue[2] ; Zhu Shunli[2] ; Bai Tongjian[3] ; Wei Qiang[3] ; Becker Benjamin[2] ; Ding Zhiyong[4] ; Wang Kai[3,5,6,7,8] ; Tian Yanghua[3,9,5,6,7,8,10,*2] ; Wang Jiaojian[1,11,*1] ;
机构： [1]State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming 650500, China. [2]School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 625014, China. [3]Department of Neurology, The First Hospital of Anhui Medical University, Hefei 230022, China. [4]Medical Imaging Department, Maternal and Child Health-care Hospital of Qujing, Qujing 655000, China. [5]Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei 230022, China. [6]Anhui Medical University, School of Mental Health and Psychological Sciences, Hefei 230022, China. [7]Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei 230022, China. [8]Anhui Province Clinical Research Center for Neurological Disease, Hefei 230022, China. [9]Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei 230088, China. [10]Department of Psychology and Sleep Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China. [11]Yunnan Key Laboratory of Primate Biomedical Research, Kunming, Yunnan 650500, China.
出处：
DOI： 10.1093/cercor/bhac311
ISSN：

关键词： default mode network major depressive disorder electroconvulsive therapy gene expression prediction

摘要：
Functional abnormalities of default mode network (DMN) have been well documented in major depressive disorder (MDD). However, the association of DMN functional reorganization with antidepressant treatment and gene expression is unclear. Moreover, whether the functional interactions of DMN could predict treatment efficacy is also unknown. Here, we investigated the link of treatment response with functional alterations of DMN and gene expression with a comparably large sample including 46 individuals with MDD before and after electroconvulsive therapy (ECT) and 46 age- and sex-matched healthy controls. Static and dynamic functional connectivity (dFC) analyses showed increased intrinsic/static but decreased dynamic functional couplings of inter- and intra-subsystems and between nodes of DMN. The changes of static functional connections of DMN were spatially correlated with brain gene expression profiles. Moreover, static and dFC of the DMN before treatment as features could predict depressive symptom improvement following ECT. Taken together, these results shed light on the underlying neural and genetic basis of antidepressant effect of ECT and the intrinsic functional connectivity of DMN have the potential to serve as prognostic biomarkers to guide accurate personalized treatment.© The Author(s) 2022. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

基金：
This work was supported by the National Natural Science Foundation of China (nos. 62176044, 32071054, and 62006220), Natural Science Foundation of Yunnan Province (nos. 202001BC070001 and 202102AA100053), Anhui Provincial Science Fund for Distinguished Young Scholars (no. 1808085J23), and the Sichuan Science and Technology Program (no. 2021YJ0186).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 2 区 医学
小类 | 2 区 神经科学
最新[2023]版：
大类 | 2 区 医学
小类 | 3 区 神经科学
第一作者：
第一作者机构： [1]State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming 650500, China. [2]School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 625014, China.
通讯作者：
通讯机构： [1]State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming 650500, China. [3]Department of Neurology, The First Hospital of Anhui Medical University, Hefei 230022, China. [5]Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei 230022, China. [6]Anhui Medical University, School of Mental Health and Psychological Sciences, Hefei 230022, China. [7]Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei 230022, China. [8]Anhui Province Clinical Research Center for Neurological Disease, Hefei 230022, China. [9]Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei 230088, China. [10]Department of Psychology and Sleep Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China. [11]Yunnan Key Laboratory of Primate Biomedical Research, Kunming, Yunnan 650500, China. [*1]State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, 650500, China [*2]Department of Neurology, the First Hospital of Anhui Medical University, Hefei, 230022, China
推荐引用方式(GB/T 7714)：
Li Yuanyuan,Yu Xiaohui,Ma Yingzi,et al.Neural signatures of default mode network in major depression disorder after electroconvulsive therapy[J].Cerebral cortex (New York, N.Y. : 1991).2022,doi:10.1093/cercor/bhac311.
APA：
Li Yuanyuan,Yu Xiaohui,Ma Yingzi,Su Jing,Li Yue...&Wang Jiaojian.(2022).Neural signatures of default mode network in major depression disorder after electroconvulsive therapy.Cerebral cortex (New York, N.Y. : 1991),,
MLA：
Li Yuanyuan,et al."Neural signatures of default mode network in major depression disorder after electroconvulsive therapy".Cerebral cortex (New York, N.Y. : 1991) .(2022)

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