机构：[1]The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China[2]Department of MRI, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China医技片磁共振科云南省第一人民医院[3]The Department of Medical Imaging, The First Affiliated Hospital of Kunming Medical University, Kunming, China昆明医科大学附属第一医院[4]School of Foreign Languages, University of Electronic Science and Technology of China, Chengdu, China[5]The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China[6]Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, China
Emerging evidence has documented the abnormalities of primary brain functions in major depressive disorder (MDD). The brainstem has shown to play an important role in regulating basic functions of the human brain, but little is known about its role in MDD, especially the roles of its subregions. To uncover this, the present study adopted resting-state functional magnetic resonance imaging with fine-grained brainstem atlas in 23 medication-free MDD patients and 34 matched healthy controls (HC). The analysis revealed significantly increased functional connectivity of the medulla, one of the brainstem subregions, with the inferior parietal cortex (IPC) in MDD patients. A positive correlation was further identified between the increased medulla-IPC functional connectivity and Hamilton anxiety scores. Functional characterization of the medulla and IPC using a meta-analysis revealed that both regions primarily participated in action execution and inhibition. Our findings suggest that increased medulla-IPC functional connectivity may be related to over-activity or abnormal control of negative emotions in MDD, which provides a new insight for the neurobiology of MDD.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [31800961, 31600880]; Sichuan Science and Technology Program [2018JY0361]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2018M633336]; Shenzhen Basic Research Project [JCYJ2017081802123707]; Chinese Fundamental Research Funding for Central Universities [ZYGX2015002]; Interdisciplinary Development Project of University of Electronic Science and Technology of China [Y03111023901014007]; Early Career Funding in Social Science [Y03001023601039010]; Science and Technology Program of Guangzhou [201807010064]
第一作者机构：[1]The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China
共同第一作者：
通讯作者：
通讯机构：[5]The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China[6]Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, China
推荐引用方式(GB/T 7714)：
Luo Lizhu,Wu Kunhua,Lu Yi,et al.Increased Functional Connectivity Between Medulla and Inferior Parietal Cortex in Medication-Free Major Depressive Disorder[J].FRONTIERS IN NEUROSCIENCE.2018,12:doi:10.3389/fnins.2018.00926.
APA：
Luo, Lizhu,Wu, Kunhua,Lu, Yi,Gao, Shan,Kong, Xiangchao...&Wang, Jiaojian.(2018).Increased Functional Connectivity Between Medulla and Inferior Parietal Cortex in Medication-Free Major Depressive Disorder.FRONTIERS IN NEUROSCIENCE,12,
MLA：
Luo, Lizhu,et al."Increased Functional Connectivity Between Medulla and Inferior Parietal Cortex in Medication-Free Major Depressive Disorder".FRONTIERS IN NEUROSCIENCE 12.(2018)
