机构：[1]Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.昆明医科大学附属第一医院[2]Department of Psychiatry, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong 519000, China[3]Department of Rheumatology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China昆明医科大学附属第一医院[4]Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China[5]Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China[6]Anhui Medical University, Hefei, Anhui 230022, China[7]Beijing Anding Hospital, Capital Medical University, Beijing 100054, China[8]Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China重庆医科大学附属第一医院[9]The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, China[10]Department of Psychiatry, Sir Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China[11]Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China[12]Department of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110001, China[13]Department of Psychiatry, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China[14]Department of Radiology, Huaxi MR Research Center, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China四川大学华西医院[15]Psychoradiology Research Unit of Chinese Academy of Medical Sciences, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China四川大学华西医院[16]Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210096, China[17]Mental Health Center, West China Hospital, Sichuan University Chengdu, Sichuan 610041, China四川大学华西医院[18]Department of Clinical Psychology, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, Jiangsu 215137, China[19]Faculty of Psychology, Southwest University, Chongqing 400716, China[20]Department of Diagnostics, Affiliated Hospital, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China[21]Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China浙江大学医学院附属第一医院[22]National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Beijing 100191, China[23]Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing 100191, China[24]Xi'an Central Hospital, Xi'an, Shaanxi 710003, China[25]Department of Neurology, Affiliated ZhongDa Hospital of Southeast University, Nanjing, Jiangsu 210009, China[26]Department of Psychiatry, The Fourth Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China[27]Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China[28]Chongqing Key Laboratory of Neurobiology, Chongqing 400016, China[29]Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China重庆医科大学附属第一医院[30]The First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi 710061, China[31]First Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China[32]Fifth People's Hospital of Zigong City, Zigong, Sichuan 643020, China[33]Research Center of Molecular Imaging, Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong 519000, China[34]Department of Psychiatry, The First Hospital of Jiaxing or The First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang 314001, China
Recently, functional homotopy (FH) architecture, defined as robust functional connectivity (FC) between homotopic regions, has been frequently reported to be altered in MDD patients (MDDs) but with divergent locations.In this study, we obtained resting-state functional magnetic resonance imaging (R-fMRI) data from 1004 MDDs (mean age, 33.88 years; age range, 18-60 years) and 898 matched healthy controls (HCs) from an aggregated dataset from 20 centers in China. We focused on interhemispheric function integration in MDDs and its correlation with clinical characteristics using voxel-mirrored homotopic connectivity (VMHC) devised to inquire about FH patterns.As compared with HCs, MDDs showed decreased VMHC in visual, motor, somatosensory, limbic, angular gyrus, and cerebellum, particularly in posterior cingulate gyrus/precuneus (PCC/PCu) (false discovery rate [FDR] q < .002, z =-7.07). Further analysis observed that the reduction in SMG and insula was more prominent with age, of which SMG reflected such age-related change in males instead of females. Besides, the reduction of MTG was found to be a male-special abnormal pattern in MDDs. VMHC alterations were markedly related to episode type and illness severity. The higher Hamilton Depression Rating Scale score, the more apparent VMHC reduction in the primary visual cortex. First-episode MDDs revealed stronger VMHC reduction in PCu relative to recurrent MDDs.We confirmed a significant VMHC reduction in MDDs in broad areas, especially in PCC/PCu. This reduction was affected by gender, age, episode type, and illness severity. These findings suggest that the depressive brain tends to disconnect information exchange across hemispheres.This article is protected by copyright. All rights reserved.
基金：
This work was supported by National Natural Science Foundation of China (82060259, 81760296,
81660237), Medical Leader Foundation of Yunnan Province (L2019011, L2019004), Famous Doctors
Project of Yunnan Province Plan (YNWR-MY-2018-040, YNWR-MY-2018-041), Applied Basic Key
Project of Yunnan Provincial Department of Science and Technology-Kunming Medical University Joint
Foundation (2017FE468(-176)).
第一作者机构：[1]Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.[34]Department of Psychiatry, The First Hospital of Jiaxing or The First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang 314001, China
通讯作者：
通讯机构：[1]Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.[*1]Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, No. 295, Xichang Road, Kunming City, Yunnan 650032, China
推荐引用方式(GB/T 7714)：
Ke Deng,Ji-Hui Yue,Jian Xu,et al.Impaired robust interhemispheric function integration of depressive brain from REST-meta-MDD database in China.[J].BIPOLAR DISORDERS.2022,24(4):400-411.doi:10.1111/bdi.13139.
APA：
Ke Deng,Ji-Hui Yue,Jian Xu,Ping-Ping Ma,Xiao Chen...&Yu-Qi Cheng.(2022).Impaired robust interhemispheric function integration of depressive brain from REST-meta-MDD database in China..BIPOLAR DISORDERS,24,(4)
MLA：
Ke Deng,et al."Impaired robust interhemispheric function integration of depressive brain from REST-meta-MDD database in China.".BIPOLAR DISORDERS 24..4(2022):400-411
